Optimizing radiolabeling amine-functionalized silica nanoparticles using SarAr-NCS for applications in imaging and radiotherapy

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dc.contributor.authorKong, Len_AU
dc.contributor.authorMume, Een_AU
dc.contributor.authorTriani, Gen_AU
dc.contributor.authorSmith, SVen_AU
dc.date.accessioned2015-10-13T00:00:05Zen_AU
dc.date.available2015-10-13T00:00:05Zen_AU
dc.date.issued2013-05-07en_AU
dc.date.statistics2015-10-02en_AU
dc.description.abstractSilica nanoparticles functionalized with amine groups and in the size range of approximately 60–94 nm were produced by combining sol–gel processing and emulsion technology. Hexa-aza cage ligand SarAr-NCS was conjugated to the silica nanoparticles and subsequently radiolabeled with a solution of 57Co2+-doped carrier Co2+. The number of Co2+ ions bound to the silica particles at pH 7 was used to determine the average number of available SarAr-NCS ligands conjugated to a silica particle. For organically modified silica particles of 94.0 and 59.5 nm diameter, the maximum number of metal binding sites was determined to be 11700 and 3270 sites per particle, respectively. For silica particles (63.5 nm peak diameter) produced using an water-in-oil emulsion, the calculated average was 4480 on the particle surface. The number of SarAr-NCS conjugated on the particles was easily controlled, potentially providing for a range of products for applications in the risk assessment of particles and theranostic imaging or radiotherapy when radiolabeled with a suitable radioisotope such as 64Cu or 67Cu. © 2013, American Chemical Society.en_AU
dc.identifier.citationKong, L., Mume, E., Triani, G., & Smith, S. V. (2013).Optimizing radiolabeling amine-functionalized silica nanoparticles using SarAr-NCS for applications in imaging and radiotherapy. Langmuir, 29(18), 5609-5616. doi:10.1021/la400630een_AU
dc.identifier.govdoc6137en_AU
dc.identifier.issn0743-7463en_AU
dc.identifier.issue18en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination5609-5616en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la400630een_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6307en_AU
dc.identifier.volume29en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectRisk assessmenten_AU
dc.subjectRadiotherapyen_AU
dc.subjectRadioisotopesen_AU
dc.subjectEmulsionsen_AU
dc.subjectRadioactivityen_AU
dc.subjectExperimental dataen_AU
dc.titleOptimizing radiolabeling amine-functionalized silica nanoparticles using SarAr-NCS for applications in imaging and radiotherapyen_AU
dc.typeJournal Articleen_AU
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