Near superhydrophobic fibrous scaffold for endothelialization: fabrication, characterization and cellular activities

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dc.contributor.authorAhmed, Fen_AU
dc.contributor.authorChoudhury, NRen_AU
dc.contributor.authorDutta, NKen_AU
dc.contributor.authorZannettino, Aen_AU
dc.contributor.authorKnott, RBen_AU
dc.date.accessioned2015-09-28T04:55:46Zen_AU
dc.date.available2015-09-28T04:55:46Zen_AU
dc.date.issued2013-10-04en_AU
dc.date.statistics2015-09-11en_AU
dc.description.abstractIn this work, we have applied an electrospinning method to control wettability and further hydrophobic modification of a hydrophobic polymer mat of poly(vinylidene fluoride-co hexafluoropropylene). A correlation between the processing parameters, rheological properties of polymer solutions, and electrospinning ability was made using the polymer’s critical entanglement concentration, the boundary between the semidilute unentangled regime and the semidilute entangled regime. The wetting behavior, structural and thermal characteristics of electrospun (ES) mats were evaluated and compared with solvent cast sample using advancing and receding contact angle analyses, differential scanning calorimetry, and small-angle X-ray scattering. To demonstrate the feasibility, the best optimized ES samples were examined for their potential and ability to support bone marrow derived endothelial cell seeding efficiency, adhesion and proliferation. Our studies show that, while different processing techniques can effectively modulate physical and morphological changes such as porosity and hydrophobicity, the cellular adhesion and proliferation are highly time-dependent and controlled by chemical factors. As such, these results suggest that it is the interplay of both physical and chemical factors that determine the endothelialization of porous near superhydrophobic scaffolds. The developed electrospun samples demonstrate their feasibility for endothelialization. © 2013, American Chemical Society.en_AU
dc.identifier.citationAhmed, F., Choudhury, N. R., Dutta, N. K., Zannettino, A., & Knott, R. (2013). Near superhydrophobic fibrous scaffold for endothelialization: fabrication, characterization and cellular activities. Biomacromolecules, 14(11), 3850-3860. doi:10.1021/bm400938nen_AU
dc.identifier.govdoc6061en_AU
dc.identifier.issn1525-­7797en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleBiomacromoleculesen_AU
dc.identifier.pagination3850-3860en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/bm400938nen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6218en_AU
dc.identifier.volume14en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectPolymersen_AU
dc.subjectPorosityen_AU
dc.subjectWettabilityen_AU
dc.subjectCell proliferationen_AU
dc.subjectProteinsen_AU
dc.subjectThermal analysisen_AU
dc.titleNear superhydrophobic fibrous scaffold for endothelialization: fabrication, characterization and cellular activitiesen_AU
dc.typeJournal Articleen_AU
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