An investigation of inconsistent projections and artefacts in multi-pinhole SPECT with axially aligned pinholes

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dc.contributor.authorKench, PLen_AU
dc.contributor.authorLin, Jen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorMeikle, SRen_AU
dc.date.accessioned2013-12-03T00:37:08Zen_AU
dc.date.available2013-12-03T00:37:08Zen_AU
dc.date.issued2011-12-07en_AU
dc.date.statistics2013-12-03en_AU
dc.description.abstractMultiple pinholes are advantageous for maximizing the use of the available field of view (FOV) of compact small animal single photon emission computed tomography (SPECT) detectors. However, when the pinholes are aligned axially to optimize imaging of extended objects, such as rodents, multiplexing of the pinhole projections can give rise to inconsistent datawhich leads to ‘ghost point’ artefacts in the reconstructed volume. A novel four pinhole collimator with a baffle was designed and implemented to eliminate these inconsistent projections. Simulation and physical phantom studies were performed to investigate artefacts from axially aligned pinholes and the efficacy of the baffle in removing inconsistent data and, thus, reducing reconstruction artefacts. SPECT was performed using a Defrise phantom to investigate the impact of collimator design on FOV utilization and axial blurring effects. Multiple pinhole SPECT acquired with a baffle had fewer artefacts and improved quantitative accuracy when compared to SPECT acquired without a baffle. The use of four pinholes positioned in a square maximized the available FOV, increased acquisition sensitivity and reduced axial blurring effects. These findings support the use of a baffle to eliminate inconsistent projection data arising from axially aligned pinholes and improve small animal SPECT reconstructions. © 2011 IOP Publishing LTDen_AU
dc.description.sponsorshipOur work was supported by an Australian Institute of Nuclear Science and Engineering Award AINGRA07083, 2007).en_AU
dc.identifier.citationKench, P. L., Lin, J., Grégoire, M. C., & Meikle, S. R. (2011). An investigation of inconsistent projections and artefacts in multi-pinhole SPECT with axially aligned pinholes. Physics in Medicine and Biology, 56(23), 7487-7503. doi:10.1088/0031-9155/56/23/010en_AU
dc.identifier.govdoc5290en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issue23en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.pagination7487-7503en_AU
dc.identifier.urihttp://dx.doi.org/10.1088/0031-9155/56/23/010en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5059en_AU
dc.identifier.volume56en_AU
dc.language.isoenen_AU
dc.publisherIOP Publishing Ltden_AU
dc.subjectPhantomsen_AU
dc.subjectSingle photon emission computed tomographyen_AU
dc.subjectAnimalsen_AU
dc.subjectRatsen_AU
dc.subjectDataen_AU
dc.subjectCollimatorsen_AU
dc.titleAn investigation of inconsistent projections and artefacts in multi-pinhole SPECT with axially aligned pinholesen_AU
dc.typeJournal Articleen_AU
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