Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway

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dc.contributor.authorChen, JZen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.contributor.authorHu, CHen_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2015-01-28T03:59:51Zen_AU
dc.date.available2015-01-28T03:59:51Zen_AU
dc.date.issued2011-06-01en_AU
dc.date.statistics2015-01-28en_AU
dc.description.abstractObesity has been associated with both the carcinogenesis and poor prognosis of colon cancer, one of the leading causes of cancer-related death. Increased blood levels of insulin in obese subjects have been demonstrated to play a key role in carcinogenesis. It is also possible that insulin affects treatment efficacy, leading to poor prognosis. In this study, we demonstrated that insulin can increase HT29 colon cancer cell line resistance to cycloheximide and 5- fluorouracil induced cytotoxicity. This effect can be inhibited by the PI3K/Akt inhibitor Ly294002, indicating the important role of this pathway in the insulin-induced inefficacy of chemotherapy. The insulin-induced resistance to cycloheximide and 5-fluorouracil can be used in drug screening to overcome the inefficacy of chemotherapy in obesity-associated colon cancer. © 2011 Bentham Science Publishersen_AU
dc.identifier.citationChen, J., Katsifis, A., Hu, C., & Huang, X-F (2011). Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway. Current Drug Discovery Technologies, 8(2), 119-25. doi:10.2174/157016311795563820en_AU
dc.identifier.govdoc5281en_AU
dc.identifier.issn1570-1638en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleCurrent Drug Discovery Technologiesen_AU
dc.identifier.pagination119-125en_AU
dc.identifier.urihttp://dx.doi.org/10.2174/157016311795563820en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6121en_AU
dc.identifier.volume8en_AU
dc.language.isoenen_AU
dc.publisherBentham Science Publishers Ltden_AU
dc.subjectInsulinen_AU
dc.subjectCycloheximideen_AU
dc.subjectMetabolic diseasesen_AU
dc.subjectFluorouracilsen_AU
dc.subjectChemotherapyen_AU
dc.subjectLarge intestineen_AU
dc.subjectNeoplasmsen_AU
dc.subjectCarcinogenesisen_AU
dc.titleInsulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathwayen_AU
dc.typeJournal Articleen_AU
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