Effects of typical and atypical antipsychotic drugs on rat brain muscarinic receptors

Simple item page
dc.contributor.authorZavitsanou, Ken_AU
dc.contributor.authorNguyen, VHen_AU
dc.contributor.authorHan, Men_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2019-11-12T03:53:33Zen_AU
dc.date.available2019-11-12T03:53:33Zen_AU
dc.date.issued2007-02-01en_AU
dc.date.statistics2019-11-12en_AU
dc.description.abstractQuantitative in vitro autoradiography was used to examine changes in muscarinic M1/M4 and M2/M4 receptors (targeted with [3H]pirenzepine and [3H]AF-DX384 respectively), in rats treated with the typical (haloperidol) and atypical (clozapine and olanzapine) antipsychotic medications for a period of 36 days. Rats were sacrificed at either 2 h or 48 h after the last drug administration to examine immediate effects as well as the effects at 48 h after drug withdrawal. Haloperidol significantly increased [3H]pirenzepine binding in the dentate gyrus (37%) and in the CA1 region of the hippocampus (34%) in animals sacrificed 2 h after the last drug administration compared to controls. Similarly, clozapine significantly increased [3H]pirenzepine binding in dentate gyrus (29%) in rats sacrificed 2 h after the last drug administration compared to controls. Haloperidol decreased [3H]AF-DX384 binding in the basolateral nucleus of the amygdala (20%) in the rats sacrificed 48 h after the last drug administration compared to controls. These findings suggest that muscarinic receptors and limbic brain regions such as hippocampus and amygdala might represent common targets that mediate beneficial clinical effects of antipsychotic drugs. © 2007 Springer Science+Business Media, LLCen_AU
dc.identifier.citationZavitsanou, K., Nguyen, V. H., Han, M., & Huang, X. F. (2007). Effects of typical and atypical antipsychotic drugs on rat brain muscarinic receptors. Neurochemical research, 32(3), 525-532. doi:10.1007/s11064-006-9266-9en_AU
dc.identifier.govdoc8911en_AU
dc.identifier.issn0364-3190en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitleNeurochemical researchen_AU
dc.identifier.pagination525-532en_AU
dc.identifier.urihttps://doi.org/10.1007/s11064-006-9266-9en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9086en_AU
dc.identifier.volume32en_AU
dc.language.isoenen_AU
dc.publisherKluwer Academic Publishers-Plenum Publishersen_AU
dc.subjectAutoradiographyen_AU
dc.subjectHippocampusen_AU
dc.subjectPharmacologyen_AU
dc.subjectReceptorsen_AU
dc.subjectBrainen_AU
dc.subjectDrugsen_AU
dc.subjectNeurologyen_AU
dc.titleEffects of typical and atypical antipsychotic drugs on rat brain muscarinic receptorsen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles