Adolescent rats find repeated Δ9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure

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dc.contributor.authorQuinn, HRen_AU
dc.contributor.authorMatsumoto, Ien_AU
dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorLong, LEen_AU
dc.contributor.authorArnold, JCen_AU
dc.contributor.authorGunasekaran, Nen_AU
dc.contributor.authorThompson, MRen_AU
dc.contributor.authorDawson, Ben_AU
dc.contributor.authorMallet, PEen_AU
dc.contributor.authorKashem, MAen_AU
dc.contributor.authorMatsda-Matsumoto, Hen_AU
dc.contributor.authorIwazki, Ten_AU
dc.contributor.authorMcGregor, ISen_AU
dc.date.accessioned2018-09-21T02:01:51Zen_AU
dc.date.available2018-09-21T02:01:51Zen_AU
dc.date.issued2007-06-20en_AU
dc.date.statistics2018-09-20en_AU
dc.description.abstractThe current study examined whether adolescent rats are more vulnerable than adult rats to the lasting adverse effects of cannabinoid exposure on brain and behavior. Male Wistar rats were repeatedly exposed to Δ9-tetrahydrocannabinol (Δ(9)-THC, 5 mg/kg i.p.) in a place-conditioning paradigm during either the adolescent (post-natal day 28+) or adult (post-natal day 60+) developmental stages. Adult rats avoided a Δ(9)-THC-paired environment after either four or eight pairings and this avoidance persisted for at least 16 days following the final Δ(9)-THC injection. In contrast, adolescent rats showed no significant place aversion. Adult Δ(9)-THC-treated rats produced more vocalizations than adolescent rats when handled during the intoxicated state, also suggesting greater drug-induced aversion. After a 10-15 day washout, both adult and adolescent Δ(9)-THC pretreated rats showed decreased social interaction, while onlyΔ (9)-THC pretreated adolescent rats showed significantly impaired object recognition memory. Seventeen days following their last Δ(9)-THC injection, rats were euthanised and hippocampal tissue processed using two-dimensional gel electrophoresis proteomics. There was no evidence of residual Δ(9)-THC being present in blood at this time. Proteomic analysis uncovered 27 proteins, many involved in regulating oxidative stress/mitochondrial functioning and cytoarchitecture, which were differentially expressed in adolescent Δ(9)-THC pretreated rats relative to adolescent controls. In adults, only 10 hippocampal proteins were differentially expressed in Δ(9)-THC compared to vehicle-pretreated controls. Overall these findings suggest that adolescent rats find repeated Δ(9)-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats. © 2018 Springer Natureen_AU
dc.identifier.citationQuinn, H. R., Matsumoto, I., Callaghan, P. D., Long, L. E., Arnold, J. C., Gunasekaran, N., Thompson, M. R., Dawson, B., Mallet, P. E., Kashem, M. A., Matsda-Matsumoto, H., Iwazki, I., & McGregor, I. S. (2007). Adolescent rats find repeated Δ9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33, 1113. doi:10.1038/sj.npp.1301475en_AU
dc.identifier.govdoc8910en_AU
dc.identifier.issn1740-634Xen_AU
dc.identifier.journaltitleNeuropsychopharmacologyen_AU
dc.identifier.pagination1113-1126en_AU
dc.identifier.urihttp://dx.doi.org/10.1038/sj.npp.1301475en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9033en_AU
dc.identifier.volume33en_AU
dc.language.isoenen_AU
dc.publisherSpringer Natureen_AU
dc.subjectRatsen_AU
dc.subjectHippocampusen_AU
dc.subjectProteinsen_AU
dc.subjectElectrophoresisen_AU
dc.subjectProteinsen_AU
dc.subjectBrainen_AU
dc.subjectDrug abuseen_AU
dc.subjectAdolescentsen_AU
dc.titleAdolescent rats find repeated Δ9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposureen_AU
dc.typeJournal Articleen_AU
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