Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice

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dc.contributor.authorYu, YHen_AU
dc.contributor.authorWu, YZen_AU
dc.contributor.authorSzabo, Aen_AU
dc.contributor.authorWang, Sen_AU
dc.contributor.authorYu, SJen_AU
dc.contributor.authorWang, Qen_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2020-03-24T22:24:46Zen_AU
dc.date.available2020-03-24T22:24:46Zen_AU
dc.date.issued2015-09-21en_AU
dc.description.abstractScope Obesity impairs cognition, and the leptin-induced increase of brain-derived neurotrophic factor (BDNF) and neurogenesis. Tea consumption improves cognition and increases brain activation in the prefrontal cortex. Methods and results This study examined whether teasaponin, an active ingredient in tea, could improve memory and central leptin effects on neurogenesis in the prefrontal cortex of obese mice, and in vitro in cultured prefrontal cortical neurons. Teasaponin (10 mg/kg, intraperitoneal) for 21 days improved downstream leptin signaling (JAK2 and STAT3), and leptin's effect on BDNF, in the prefrontal cortex of high-fat diet (HFD) fed mice. Prefrontal cortical neurons were cultured with teasaponin and palmitic acid (the most abundant dietary saturated fatty acid) to examine their effects on neurogenesis and BDNF expression in response to leptin. Palmitic acid decreased leptin's effect on neurite outgrowth, postsynaptic density protein 95, and BDNF expression in cultured cortical neurons, which was reversed by teasaponin. Conclusion Teasaponin improved the leptin sensitivity of prefrontal cortical neurons in obese mice or when treated by palmitic acid. This in turn increased BDNF expression and neurite growth. Therefore, teasaponin supplementation may be used to prevent obesity-associated neurodegeneration and improve cognitive function. © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheimen_AU
dc.identifier.citationYu, Y., Wu, Y., Szabo, A., Wang, S., Yu, S., Wang, Q., & Huang, X. F. (2015). Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice. Molecular Nutrition & Food Research, 59(12), 2371-2382. doi:10.1002/mnfr.201500205en_AU
dc.identifier.govdoc8907en_AU
dc.identifier.issn1613-4133en_AU
dc.identifier.issue12en_AU
dc.identifier.journaltitleMolecular Nutrition & Food Researchen_AU
dc.identifier.pagination2371-2382en_AU
dc.identifier.urihttps://doi.org/10.1002/mnfr.201500205en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9227en_AU
dc.identifier.volume59en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley and Sonsen_AU
dc.subjectMetabolic diseasesen_AU
dc.subjectLeptinen_AU
dc.subjectBrainen_AU
dc.subjectCerebral cortexen_AU
dc.subjectBeveragesen_AU
dc.subjectFatsen_AU
dc.subjectDieten_AU
dc.subjectMiceen_AU
dc.titleTeasaponin improves leptin sensitivity in the prefrontal cortex of obese miceen_AU
dc.typeJournal Articleen_AU
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