[18F]Radiochemistry using the nano tek microfluidic synthesis system

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dc.contributor.authorMatesic, Len_AU
dc.date.accessioned2020-03-24T22:16:37Zen_AU
dc.date.available2020-03-24T22:16:37Zen_AU
dc.date.issued2013-08-21en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractThe use of continuous-flow microfluidics in radiochemistry has only emerged in recent years.[1,2] Microfluidic devices feature channels with internal diameters of 10–300 µm, which process fluids with high speed and precision, resulting in improved mixing efficiency. Other advantages of microfluidic technology include shorter reaction times, greater radiochemical yield (RCY), and reduced consumption of reagents.[3] Recently, the first account of a positron emission tomography (PET) radiotracer for human use produced on a batch-mode microfluidics system was reported.[4] Currently, the most employed commercial microfluidic system in radiochemistry is the NanoTek Microfluidic Synthesis System manufactured by Advion[5] (Fig. 1) and its components and method of operation have been described in detail previously.[6] Although the system has been applied to radiochemical syntheses using radioisotopes such as carbon-11,[7] nitrogen-13,[8] and technetium-99m,[9] the overwhelming majority of research using the NanoTek system has been directed towards fluorine-18 (18F, t1/2 = 109.7 min) radiochemistry. Some recent, noteworthy examples are highlighted below and their results compared with conventional radiochemical methods. © 2013 CSIRO Publishingen_AU
dc.identifier.citationMatesic, L. (2013). [18F] Radiochemistry using the NanoTek Microfluidic Synthesis System. Australian Journal of Chemistry, 66(11), 1459-1460. doi.org/10.1071/CH13285en_AU
dc.identifier.govdoc8906en_AU
dc.identifier.issn0004-9425en_AU
dc.identifier.issue66en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleAustralian Journal of Chemistryen_AU
dc.identifier.pagination1459-1460en_AU
dc.identifier.urihttps://doi.org/10.1071/CH13285en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9226en_AU
dc.language.isoenen_AU
dc.publisherCSIRO Publishingen_AU
dc.subjectRadiochemistryen_AU
dc.subjectFluidsen_AU
dc.subjectNanotechnologyen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectSynthesisen_AU
dc.subjectCarbonen_AU
dc.subjectNitrogenen_AU
dc.title[18F]Radiochemistry using the nano tek microfluidic synthesis systemen_AU
dc.typeJournal Articleen_AU
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