Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats

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dc.contributor.authorWu, ZXen_AU
dc.contributor.authorYu, YHen_AU
dc.contributor.authorWu, YZen_AU
dc.contributor.authorPatch, Cen_AU
dc.contributor.authorSzabo, Aen_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2020-03-29T19:31:14Zen_AU
dc.date.available2020-03-29T19:31:14Zen_AU
dc.date.issued2013-08-01en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractHigh-fat (HF) diet and obesity are risk factors for a number of mental health problems including depression, cognitive dysfunction, dementia, and neurodegenerative diseases. Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study examined H1R receptor binding density in the brain of male rats fed a high-saturated fat (HF) diet, as well as the effect of docosahexaenoic acid (DHA), galacto-oligosaccharide (GOS) and resistant starch (RS) supplementation of HF diet. Alterations of H1R expression in the post-mortem rat brain were detected by [3H]-pyrilamine binding autoradiography. We found that HF diet significantly decreased H1R binding densities in the substantia nigra (SN), caudate putamen (CPu), hypothalamic arcuate nucleus (Arc), ventral tegmental area (VTA), piriform cortex (Pir) and primary motor cortex (M1), compared with low-fat fed rats, and the suppression of receptor binding density ranged from 31% to 48%. Interestingly, supplementing the HF diet with 0.5% n-3 polyunsaturated docosahexaenoic acid (DHA) prevented reduction of H1R binding densities in the SN and CPu. Addition of galacto-oligosaccharide (GOS) and resistant starch (RS) to the diet blunted HF induced reduction of H1R ligand binding in the SN and Pir, respectively. In conclusion this study showed that HF diet can alter H1R binding densities in various brain regions, and many of these changes can be prevented by adding DHA, GOS or RS to the diet. © 2013 Elsevier Inc.en_AU
dc.identifier.citationWu, Z., Yu, Y., Wu, Y., Patch, C., Szabo, A., & Huang, X. F. (2013). Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. Brain Research Bulletin, 97, 119-125. doi:10.1016/j.brainresbull.2013.06.003en_AU
dc.identifier.govdoc8904en_AU
dc.identifier.issn0361-9230en_AU
dc.identifier.journaltitleBrain Research Bulletinen_AU
dc.identifier.pagination119-125en_AU
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2013.06.003en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9280en_AU
dc.identifier.volume97en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectHistamineen_AU
dc.subjectReceptorsen_AU
dc.subjectCarboxylic acidsen_AU
dc.subjectLactoseen_AU
dc.subjectStarchen_AU
dc.subjectAutoradiographyen_AU
dc.subjectCentral nervous systemen_AU
dc.subjectProteinsen_AU
dc.titleReduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male ratsen_AU
dc.typeJournal Articleen_AU
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