Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA – first small animal PET results

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dc.contributor.authorReischl, Gen_AU
dc.contributor.authorDorow, Den_AU
dc.contributor.authorCullinane, Cen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.contributor.authorRoselt, Pen_AU
dc.contributor.authorBinns, Den_AU
dc.contributor.authorHicks, RJen_AU
dc.date.accessioned2020-03-29T20:56:08Zen_AU
dc.date.available2020-03-29T20:56:08Zen_AU
dc.date.issued2007-06-14en_AU
dc.description.abstractPURPOSE: This study was performed to compare the 2-nitroimidazole derivatives [124I]IAZA, [18F]FAZA and well known [18F]FMISO in visualization of tumor hypoxia in a mouse model of human cancer using small animal PET. METHODS: PET imaging of female Balb/c nude mice bearing A431 tumors on a Phillips Mosaic small animal PET scanner was performed 3 h p.i. for all three tracers. Mice injected with [124I]IAZA were scanned again after 24 h and 48 h. In addition to the mice breathing air, in the case of [18F]FAZA and [124I]IAZA a second group of mice for each tracer was kept in an atmosphere of carbogen gas (5% of CO2 + 95 % of O2; from 1 h before to 3 h after injection) to evaluate the oxygenation dependency on uptake (all experiments n = 4). After the final PET scan animals were sacrificed and biodistribution was studied. RESULTS: Mice injected with [18F]FAZA displayed significantly higher tumor-to background (T/B) ratios (5.19 +/- 0.73) compared to those injected with [18F]FMISO (3.98 +/- 0.66; P $lt; 0.05) or [124I]IAZA (2.06 +/- 0.26; P $lt; 0.001) 3 h p.i. Carbogen breathing mice showed lower ratios ([18F]FAZA: 4.06 +/- 0.59; [124I]IAZA: 2.02 +/- 0.36). The T/B ratios increased for [124I]IAZA with time (24 h: 3.83 +/- 0.61; 48 h: 4.20 +/- 0.80), but after these late time points the absolute whole body activity was very low, as could be seen from the biodistribution data (< 0.1 %ID/g for each investigated organ) and ratios were still lower than for [18F]FAZA 3 h p.i. Due to de-iodination uptake in thyroid was high. Biodistribution data were in good agreement with the PET results. CONCLUSIONS: [18F]FAZA showed superior biokinetics compared to [18F]FMISO and [124I]IAZA in this study. Imaging at later time points that are not possible with the short lived 18F labeled tracers resulted in no advantage for [124I]IAZA, i. e. tumor to normal tissue ratios could not be improved. © 1999 Canadian Society for Pharmaceutical Sciences.en_AU
dc.identifier.citationReischl, G., Dorow, D. S., Cullinane, C., Katsifis, A., Roselt, P., Binns, D., & Hicks, R. J. (2007). Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results. Journal of Pharmacy & Pharmaceutical Sciences, 10(2), 203–211. https://sites.ualberta.ca/~csps/JPPS10_2/7/final.pdfen_AU
dc.identifier.govdoc8871en_AU
dc.identifier.issn1482-1826en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleJournal of Pharmacy & Pharmaceutical Sciencesen_AU
dc.identifier.pagination203-211en_AU
dc.identifier.urihttps://sites.ualberta.ca/~csps/JPPS10_2/7/final.pdfen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9286en_AU
dc.identifier.volume10en_AU
dc.language.isoenen_AU
dc.publisherCanadian Society for Pharmaceutical Sciencesen_AU
dc.subjectAnoxiaen_AU
dc.subjectNeoplasmsen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectFluorine 18en_AU
dc.subjectIodine 124en_AU
dc.subjectAnimalsen_AU
dc.subjectLaboratory animalsen_AU
dc.subjectMiceen_AU
dc.titleImaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA – first small animal PET resultsen_AU
dc.typeJournal Articleen_AU
oaire.citation.volume10en_AU
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