Synthesis and stability studies of Ga‐67 labeled phosphonium salts

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dc.contributor.authorKardashinsky, Men_AU
dc.contributor.authorLengkeek, NAen_AU
dc.contributor.authorRendina, LMen_AU
dc.date.accessioned2020-03-29T23:58:31Zen_AU
dc.date.available2020-03-29T23:58:31Zen_AU
dc.date.issued2016-11-07en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractDelocalized lipophilic cations such as tri- and tetra-arylphosphonium are able to diffuse across the mitochondrial membrane, which allows them to selectively accumulate in cells with a high transmembrane potential (ΔΨm). The mitochondrial membrane potential of cancer cells and cardiomyocytes has been reported to be significantly higher than that of normal epithelial cells. This feature can be exploited for the selective accumulation of phosphonium derivatives for the purposes of molecular imaging using radionuclides. Four structurally related Ga(III)-phosphonium salts were synthesized and fully characterized and found to be modest in toxicity toward T98G human glioblastoma cells (IC50 > 4 mM). High-activity (100 MBq) analogs containing Ga-67 were also synthesized and their stabilities in phosphate-buffered saline and human serum were determined. © 2016 John Wiley & Sons, Ltd.en_AU
dc.identifier.citationKardashinsky, M., Lengkeek, N., & Rendina, L. M. (2017). Synthesis and stability studies of Ga‐67 labeled phosphonium salts. Journal of Labelled Compounds and Radiopharmaceuticals, 60(1), 4-11. doi:10.1002/jlcr.3448en_AU
dc.identifier.govdoc8778en_AU
dc.identifier.issn1099-1344en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleJournal of Labelled Compounds and Radiopharmaceuticalsen_AU
dc.identifier.pagination4-11en_AU
dc.identifier.urihttps://doi.org/10.1002/jlcr.3448en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9301en_AU
dc.identifier.volume60en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley and Sonsen_AU
dc.subjectSynthesisen_AU
dc.subjectGallium 67en_AU
dc.subjectSaltsen_AU
dc.subjectMitochondriaen_AU
dc.subjectMembranesen_AU
dc.subjectGliomasen_AU
dc.subjectNeoplasmsen_AU
dc.titleSynthesis and stability studies of Ga‐67 labeled phosphonium saltsen_AU
dc.typeJournal Articleen_AU
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