Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque

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dc.contributor.authorHolland, JPen_AU
dc.contributor.authorLiang, SHen_AU
dc.contributor.authorRotstein, BHen_AU
dc.contributor.authorCollier, TLen_AU
dc.contributor.authorStephenson, NAen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorVasdev, Nen_AU
dc.date.accessioned2018-09-14T01:57:17Zen_AU
dc.date.available2018-09-14T01:57:17Zen_AU
dc.date.issued2013-12-11en_AU
dc.date.statistics2018-09-10en_AU
dc.description.abstractAlzheimer's disease (AD) and related dementias show increasing clinical prevalence, yet our understanding of the etiology and pathobiology of disease-related neurodegeneration remains limited. In this regard, noninvasive imaging with radiotracers for positron emission tomography (PET) presents a unique tool for quantifying spatial and temporal changes in characteristic biological markers of brain disease and for assessing potential drug efficacy. PET radiotracers targeting different protein markers are being developed to address questions pertaining to the molecular and/or genetic heterogeneity of AD and related dementias. For example, radiotracers including [11C]-PiB and [18F]-AV-45 (Florbetapir) are being used to measure the density of Aβ-plaques in AD patients and to interrogate the biological mechanisms of disease initiation and progression. Our focus is on the development of novel PET imaging agents, targeting proteins beyond Aβ-plaques, which can be used to investigate the broader mechanism of AD pathogenesis. Here, we present the chemical basis of various radiotracers which show promise in preclinical or clinical studies for use in evaluating the phenotypic or biochemical characteristics of AD. Radiotracers for PET imaging neuroinflammation, metal ion association with Aβ-plaques, tau protein, cholinergic and cannabinoid receptors, and enzymes including glycogen-synthase kinase-3β and monoamine oxidase B amongst others, and their connection to AD are highlighted. Copyright © 2013 John Wiley & Sons, Ltd.en_AU
dc.identifier.citationHolland, J. P., Liang, S. H., Rotstein, B. H., Collier, T. L., Stephenson, N. A., Greguric, I., & Vasdev, N. (2014). Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque. Journal of Labelled Compounds and Radiopharmaceuticals, 57(4), 323-331. doi:10.1002/jlcr.3158en_AU
dc.identifier.govdoc8770en_AU
dc.identifier.issn1099-1344en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleJournal of Labelled Compounds and Radiopharmaceuticalsen_AU
dc.identifier.pagination323-331en_AU
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/jlcr.3158en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/8983en_AU
dc.identifier.volume57en_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.subjectAgingen_AU
dc.subjectPlaque formationen_AU
dc.subjectAcetylcholineen_AU
dc.subjectEstersen_AU
dc.subjectMetalsen_AU
dc.subjectTracer techniquesen_AU
dc.subjectBioassayen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectEtiologyen_AU
dc.subjectBrainen_AU
dc.titleAlternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaqueen_AU
dc.typeJournal Articleen_AU
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