Partial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortex

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dc.contributor.authorChohan, TWen_AU
dc.contributor.authorNguyen, APen_AU
dc.contributor.authorTodd, SMen_AU
dc.contributor.authorBennett, MRen_AU
dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorArnold, JCen_AU
dc.date.accessioned2020-03-29T23:57:08Zen_AU
dc.date.available2020-03-29T23:57:08Zen_AU
dc.date.issued2014-09-29en_AU
dc.description.abstractSchizophrenia is thought to arise due to a complex interaction between genetic and environmental factors during early neurodevelopment. We have recently shown that partial genetic deletion of the schizophrenia susceptibility gene neuregulin 1 (Nrg1) and adolescent stress interact to disturb sensorimotor gating, neuroendocrine activity and dendritic morphology in mice. Both stress and Nrg1 may have converging effects upon N-methyl-D-aspartate receptors (NMDARs) which are implicated in the pathogenesis of schizophrenia, sensorimotor gating and dendritic spine plasticity. Using an identical repeated restraint stress paradigm to our previous study, here we determined NMDAR binding across various brain regions in adolescent Nrg1 heterozygous (HET) and wild-type (WT) mice using [3H] MK-801 autoradiography. Repeated restraint stress increased NMDAR binding in the ventral part of the lateral septum (LSV) and the dentate gyrus (DG) of the hippocampus irrespective of genotype. Partial genetic deletion of Nrg1 interacted with adolescent stress to promote an altered pattern of NMDAR binding in the infralimbic (IL) subregion of the medial prefrontal cortex. In the IL, whilst stress tended to increase NMDAR binding in WT mice, it decreased binding in Nrg1 HET mice. However, in the DG, stress selectively increased the expression of NMDAR binding in Nrg1 HET mice but not WT mice. These results demonstrate a Nrg1-stress interaction during adolescence on NMDAR binding in the medial prefrontal cortex. © 2014 Chohan, Nguyen, Todd, Bennett, Callaghan and Arnold this is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)en_AU
dc.identifier.citationChohan, T. W., Nguyen, A., Todd, S. M., Bennett, M. R., Callaghan, P., & Arnold, J. C. (2014). Partial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortex. Frontiers in Behavioral Neuroscience, 8, 298. doi:10.3389/fnbeh.2014.00298en_AU
dc.identifier.govdoc8697en_AU
dc.identifier.issn1662-5153en_AU
dc.identifier.issue298en_AU
dc.identifier.journaltitleFrontiers in Behavioral Neuroscienceen_AU
dc.identifier.pagination298en_AU
dc.identifier.urihttp://doi.org/10.3389/fnbeh.2014.00298en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9300en_AU
dc.identifier.volume8en_AU
dc.language.isoenen_AU
dc.publisherFrontiersen_AU
dc.subjectAdolescentsen_AU
dc.subjectBiological stressen_AU
dc.subjectHippocampusen_AU
dc.subjectBrainen_AU
dc.subjectMental disordersen_AU
dc.subjectCerebral cortexen_AU
dc.titlePartial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortexen_AU
dc.typeJournal Articleen_AU
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