Synthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imaging

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dc.contributor.authorBourdier, Ten_AU
dc.contributor.authorFookes, CJRen_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorGreguric, IDen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2020-03-25T00:06:47Zen_AU
dc.date.available2020-03-25T00:06:47Zen_AU
dc.date.issued2008-09-25en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractinThe F-18 labelled methionine derivative S-(2-[18F]fluoroethyl)-L-homocysteine ([18F]FEHCys) was prepared by a one-pot two-step synthesis via the protected S-(2-bromoethyl)-L-homocysteine 1 and S-(2-chloroethyl)-L-homocysteine 2 precursors. The bromoethyl derivative 1 gave higher radiochemical yields (40% at 5 min) at 100°C compared with the chloro-analogue (22% at 100°C in 30 min). However, [18F]FEHCys was found to be unstable in aqueous systems being transformed to the corresponding hydroxyl derivative within 20 min. © 2008 John Wiley & Sons, Ltd.en_AU
dc.identifier.citationBourdier, T., Fookes, C. J. R., Pham, T. Q., Greguric, I., & Katsifis, A. (2008). Synthesis and stability of S‐(2‐[18F] fluoroethyl)‐L‐homocysteine for potential tumour imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 51(11), 369-373. doi:10.1002/jlcr.1539en_AU
dc.identifier.govdoc8682en_AU
dc.identifier.issn1099-1344en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleJournal of Labelled Compounds and Radiopharmaceuticalsen_AU
dc.identifier.pagination369-373en_AU
dc.identifier.urihttp://doi.org/10.1002/jlcr.1539en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9230en_AU
dc.identifier.volume51en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley and Sonsen_AU
dc.subjectSynthesisen_AU
dc.subjectFluoreneen_AU
dc.subjectHomocysteineen_AU
dc.subjectRadiochemistryen_AU
dc.subjectHydroxyl radicalsen_AU
dc.subjectRadicalsen_AU
dc.titleSynthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imagingen_AU
dc.typeJournal Articleen_AU
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