NEMA NU 4-2008 validation and applications of the PET-SORTEO Monte Carlo simulations platform for the geometry of the Inveon PET preclinical scanner

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dc.contributor.authorBoisson, Fen_AU
dc.contributor.authorWimberley, CAen_AU
dc.contributor.authorLehnert, Wen_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorPerkins, Gen_AU
dc.contributor.authorHamze, Hen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorReilhac, Aen_AU
dc.date.accessioned2020-03-12T00:04:30Zen_AU
dc.date.available2020-03-12T00:04:30Zen_AU
dc.date.issued2013-09-10en_AU
dc.date.statistics2020-03-11en_AU
dc.description.abstractMonte Carlo-based simulation of positron emission tomography (PET) data plays a key role in the design and optimization of data correction and processing methods. Our first aim was to adapt and configure the PET-SORTEO Monte Carlo simulation program for the geometry of the widely distributed Inveon PET preclinical scanner manufactured by Siemens Preclinical Solutions. The validation was carried out against actual measurements performed on the Inveon PET scanner at the Australian Nuclear Science and Technology Organisation in Australia and at the Brain and Mind Research Institute and by strictly following the NEMA NU 4-2008 standard. The comparison of simulated and experimental performance measurements included spatial resolution, sensitivity, scatter fraction and count rates, image quality and Derenzo phantom studies. Results showed that PET-SORTEO reliably reproduces the performances of this Inveon preclinical system. In addition, imaging studies showed that the PET-SORTEO simulation program provides raw data for the Inveon scanner that can be fully corrected and reconstructed using the same programs as for the actual data. All correction techniques (attenuation, scatter, randoms, dead-time, and normalization) can be applied on the simulated data leading to fully quantitative reconstructed images. In the second part of the study, we demonstrated its ability to generate fast and realistic biological studies. PET-SORTEO is a workable and reliable tool that can be used, in a classical way, to validate and/or optimize a single PET data processing step such as a reconstruction method. However, we demonstrated that by combining a realistic simulated biological study ([11C]Raclopride here) involving different condition groups, simulation allows one also to assess and optimize the data correction, reconstruction and data processing line flow as a whole, specifically for each biological study, which is our ultimate intent. © 2017 IOP Publishingen_AU
dc.identifier.citationBoisson, F., Wimberley, C. J., Lehnert, W., Zahra, D., Pham, T., Perkins, G., Hamze, H. Grégoire, M. C. & Reilhac, A. (2013). NEMA NU 4-2008 validation and applications of the PET-SORTEO Monte Carlo simulations platform for the geometry of the Inveon PET preclinical scanner. Physics in Medicine and Biology, 58(19), 6749-6763. doi.10.1088/0031-9155/58/19/6749.en_AU
dc.identifier.govdoc8668en_AU
dc.identifier.issn1361-6560en_AU
dc.identifier.issue19en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.pagination6749-6763en_AU
dc.identifier.urihttp://dx.doi.org/10.1088/0031-9155/58/19/6749en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9140en_AU
dc.identifier.volume58en_AU
dc.language.isoenen_AU
dc.publisherIOP Publishingen_AU
dc.subjectSingle photon emission computed tomographyen_AU
dc.subjectMonte Carlo Methoden_AU
dc.subjectNuclear medicineen_AU
dc.subjectBodyen_AU
dc.subjectCrystalsen_AU
dc.subjectSimulationen_AU
dc.subjectData processingen_AU
dc.titleNEMA NU 4-2008 validation and applications of the PET-SORTEO Monte Carlo simulations platform for the geometry of the Inveon PET preclinical scanneren_AU
dc.typeJournal Articleen_AU
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