Progressive metabolic and structural cerebral perturbations following traumatic brain injury: an in vivo imaging study in the rat

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dc.contributor.authorLiu, YRen_AU
dc.contributor.authorCardamone, Len_AU
dc.contributor.authorHogan, REen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorWilliams, JPen_AU
dc.contributor.authorHicks, RJen_AU
dc.contributor.authorBinns, Den_AU
dc.contributor.authorKoe, Aen_AU
dc.contributor.authorJones, NCen_AU
dc.contributor.authorMyers, DEen_AU
dc.contributor.authorO'Brien, TJen_AU
dc.contributor.authorBouilleret, DEen_AU
dc.date.accessioned2014-10-01T04:56:16Zen_AU
dc.date.available2014-10-01T04:56:16Zen_AU
dc.date.issued2010-01-01en_AU
dc.description.abstractTraumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic and structural changes in rat brains were assessed after TBI using serial 18F-FDG PET and 3-dimensional MRI in vivo. Methods: Rats underwent lateral fluid percussion injury (FPI; n = 16) or a sham procedure (n = 11). PET and MR images were acquired at 1 wk and at 1, 3, and 6 mo after injury. Morphologic changes were assessed using MRI-based regions of interest, and hippocampal shape changes were assessed with large-deformation high-dimensional mapping. Metabolic changes were assessed using region-of-interest analysis and statistical parametric mapping with the flexible factorial analysis. Anxiety-like behavior and learning were assessed at 1, 3, and 6 mo after injury. Results: PET analyses showed widespread hypometabolism in injured rats, in particular involving the ipsilateral cortex, hippocampus, and amygdalae, present at 1 wk after FPI, most prominent at 1 mo, and then decreasing. Compared with the sham group, rats in the FPI group had decreased structural volume which progressively increased over 3–6 mo, occurring in the ipsilateral cortex, hippocampus, and ventricles after FPI (P < 0.05). Large-deformation high-dimensional mapping showed evolving hippocampal shape changes across the 6 mo after FPI. Injured rats displayed increased anxiety-like behavior (P < 0.05), but there were no direct correlations between the severity of the behavior abnormalities and functional or structural imaging changes. Conclusion: In selected brain structures, FPI induces early hypometabolism and delayed progressive atrophic changes that are dynamic and continue to evolve for months. These findings have implications for the understanding of the pathophysiology and evolution of long-term neurologic morbidity following TBI, and indicate an extended window for targeted neuroprotective interventions. © 2010, Society of Nuclear Medicineen_AU
dc.identifier.citationLiu, Y. R., Cardamone, L., Hogan, R. E., Grégoire, M. C., Williams, J. P., Hicks, R. J., Binns, D., Koe, A., Jones, N. C., Myers, D. E., O'Brien, T. J., & Bouilleret, V. (2010). Progressive metabolic and structural cerebral perturbations after traumatic brain injury: an in vivo imaging study in the rat. Journal of Nuclear Medicine, 51(11), 1788-1795. doi:10.2967/jnumed.110.078626en_AU
dc.identifier.govdoc5686en_AU
dc.identifier.issn0161-5505en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitleJournal of Nuclear Medicineen_AU
dc.identifier.pagination1788-1795en_AU
dc.identifier.urihttp://jnm.snmjournals.org/content/51/11/1788en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5883en_AU
dc.identifier.volume51en_AU
dc.language.isoenen_AU
dc.publisherSociety of Nuclear Medicineen_AU
dc.subjectNeurologyen_AU
dc.subjectDisease incidenceen_AU
dc.subjectMorphologyen_AU
dc.subjectBehavioren_AU
dc.subjectMammalsen_AU
dc.subjectBrainen_AU
dc.titleProgressive metabolic and structural cerebral perturbations following traumatic brain injury: an in vivo imaging study in the raten_AU
dc.typeJournal Articleen_AU
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