Comparison of cannabinoid CB1 receptor binding in adolescent and adult rats: a positron emission tomography study using [18F]MK-947

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dc.contributor.authorVerdurand, Men_AU
dc.contributor.authorNguyen, VHen_AU
dc.contributor.authorStark, Den_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2014-09-23T05:55:18Zen_AU
dc.date.available2014-09-23T05:55:18Zen_AU
dc.date.issued2011-01-01en_AU
dc.date.statistics2014-09-23en_AU
dc.description.abstractDespite the important role of cannabinoid CB1 receptors (CB1R) in brain development, little is known about their status during adolescence, a critical period for both the development of psychosis and for initiation to substance abuse. In the present study, we assessed the ontogeny of CB1R in adolescent and adult rats in vivo using positron emission tomography with [18F]MK-9470. Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [18F]MK-9470 values between the two groups revealed a main effect of age ( 𝐹 ( 1 , 1 0 9 ) = 5 . 0 , 𝑃 = 0 . 0 2 ) on [18F]MK-9470 absolute binding (calculated as percentage of injected dose) with adult estimated marginal means being higher compared to adolescents amongst 11 brain regions. This finding was confirmed using in vitro autoradiography with [3H]CP55,940 ( 𝐹 ( 1 0 , 9 9 ) = 1 4 0 . 1 , 𝑃 < 0 . 0 0 0 1 ). This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period. Copyright © 2011 Mathieu Verdurand et al.en_AU
dc.description.sponsorshipThis work is supported by the Schizophrenia Research Institute (SRI), Australia, utilizing infrastructure funding from NSW Health and by an internal Australian Nuclear Science and Technology Organisation Senior Research Fellowship to K. Zavitsanou.en_AU
dc.identifier.articlenumber548123en_AU
dc.identifier.citationVerdurand, M., Nguyen, V., Stark, D., Zahra, D., Grégoire, M. C., Greguric, I., & Zavitsanou, K. (2011). Comparison of cannabinoid CB1 receptor binding in adolescent and adult rats: a positron emission tomography study using [18F]MK-947. International Journal of Molecular Imaging, 2011, 548123. doi:10.1155/2011/548123en_AU
dc.identifier.govdoc5298en_AU
dc.identifier.issn2090-1712en_AU
dc.identifier.journaltitleInternational Journal of Molecular Imagingen_AU
dc.identifier.urihttp://dx.doi.org/10.1155/2011/548123en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5879en_AU
dc.identifier.volume2011en_AU
dc.language.isoenen_AU
dc.publisherHindawi Publishing Corporationen_AU
dc.subjectMammalsen_AU
dc.subjectAdolescentsen_AU
dc.subjectIn vivoen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectTomographyen_AU
dc.subjectAutoradiographyen_AU
dc.titleComparison of cannabinoid CB1 receptor binding in adolescent and adult rats: a positron emission tomography study using [18F]MK-947en_AU
dc.typeJournal Articleen_AU
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