Prediction of synergistic antitumour effect of gefitinib and radiation in vitro

Simple item page
dc.contributor.authorLin, HQen_AU
dc.contributor.authorMeriaty, Hen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2014-01-29T05:16:59Zen_AU
dc.date.available2014-01-29T05:16:59Zen_AU
dc.date.issued2011-09-01en_AU
dc.date.statistics2014-01-29en_AU
dc.description.abstractAIM: This study investigated the potential of a series of biomarkers in predicting the interaction of gefitinib and radiation in tumour treatment. MATERIALS AND METHODS: In vitro assays were performed on human skin cancer and melanoma cell lines. The antitumour effect was measured by using the MTT assay. Total and phosphorylated epidermal growth factor receptor (EGFR and pEGFR) levels were determined by cell-based ELISA. RESULTS: Gefitinib and radiation interacted to inhibit tumour cell proliferation in a cell line-dependent manner. Synergism dominated the interaction (76%), followed by additive effect (20%) and a few instances of antagonism (4%). Correlation analyses revealed a significant correlation between the median combination index (CI) and gefitinib IC950), radiation ID(50, gefitinib- or EGF-modulated EGFR and/or pEGFR expression (all p ≤ 0.05). CONCLUSION: A potential role of gefitinib efficacy, radiation efficacy and gefitinib- or EGF-modulated EGFR and/or pEGFR expression in the prediction of interaction between gefitinib and radiation is supported. Copyright © 2011 The International Institute of Anticancer Research.en_AU
dc.identifier.citationLin, H. Q., Meriaty, H., & Katsifis, A. (2011). Prediction of synergistic antitumour effect of gefitinib and radiation in vitro. Anticancer Research, 31(9), 2883-2888. Retrieved from http://ar.iiarjournals.org/content/31/9/2883.fullen_AU
dc.identifier.govdoc5293en_AU
dc.identifier.issn0250-7005en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitleAnticancer Researchen_AU
dc.identifier.pagination2883-2888en_AU
dc.identifier.urihttp://ar.iiarjournals.org/content/31/9/2883.fullen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5197en_AU
dc.identifier.volume31en_AU
dc.language.isoenen_AU
dc.publisherThe International Institute of Anticancer Researchen_AU
dc.subjectNeoplasmsen_AU
dc.subjectCarcinomasen_AU
dc.subjectChemotherapyen_AU
dc.subjectRadiationsen_AU
dc.subjectRadiotherapyen_AU
dc.subjectSynergismen_AU
dc.titlePrediction of synergistic antitumour effect of gefitinib and radiation in vitroen_AU
dc.typeJournal Articleen_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2883.full.pdf
Size:
216.08 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles