Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet

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dc.contributor.authorWu, YZen_AU
dc.contributor.authorYu, YHen_AU
dc.contributor.authorSzabo, Aen_AU
dc.contributor.authorHan, Men_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2018-09-21T01:36:06Zen_AU
dc.date.available2018-09-21T01:36:06Zen_AU
dc.date.issued2014-03-27en_AU
dc.date.statistics2018-09-20en_AU
dc.description.abstractA low-grade pro-inflammatory state is at the pathogenic core of obesity and type 2 diabetes. We tested the hypothesis that the plant terpenoid compound ginsenoside Rb1 (Rb1), known to exert anti-inflammatory effects, would ameliorate obesity, obesity-associated inflammation and glucose intolerance in the high-fat diet-induced obese mouse model. Furthermore, we examined the effect of Rb1 treatment on central leptin sensitivity and the leptin signaling pathway in the hypothalamus. We found that intraperitoneal injections of Rb1 (14 mg/kg, daily) for 21 days significantly reduced body weight gain, fat mass accumulation, and improved glucose tolerance in obese mice on a HF diet compared to vehicle treatment. Importantly, Rb1 treatment also reduced levels of pro-inflammatory cytokines (TNF-α, IL-6 and/or IL-1β) and NF-κB pathway molecules (p-IKK and p-IκBα) in adipose tissue and liver. In the hypothalamus, Rb1 treatment decreased the expression of inflammatory markers (IL-6, IL-1β and p-IKK) and negative regulators of leptin signaling (SOCS3 and PTP1B). Furthermore, Rb1 treatment also restored the anorexic effect of leptin in high-fat fed mice as well as leptin pSTAT3 signaling in the hypothalamus. Ginsenoside Rb1 has potential for use as an anti-obesity therapeutic agent that modulates obesity-induced inflammation and improves central leptin sensitivity in HF diet-induced obesity. © 2014 Wu et al.en_AU
dc.description.sponsorshipAcquired from the Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2014 Wu et al.en_AU
dc.identifier.articlenumbere92618en_AU
dc.identifier.citationWu, Y., Yu, Y., Szabo, A., Han, M., & Huang, X. F. (2014). Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet. PloS one, 9(3), e92618. doi:10.1371/journal.pone.0092618en_AU
dc.identifier.govdoc8903en_AU
dc.identifier.issn1932-6203en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitlePloS oneen_AU
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0092618en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9032en_AU
dc.identifier.volume9en_AU
dc.language.isoenen_AU
dc.publisherPublic Library of Scienceen_AU
dc.subjectLeptinen_AU
dc.subjectMetabolic diseasesen_AU
dc.subjectInflammationen_AU
dc.subjectHypothalamusen_AU
dc.subjectDieten_AU
dc.subjectFatsen_AU
dc.subjectWeighten_AU
dc.subjectBodyen_AU
dc.subjectMiceen_AU
dc.titleCentral inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat dieten_AU
dc.typeJournal Articleen_AU
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