Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation

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dc.contributor.authorReilhac, Aen_AU
dc.contributor.authorBoisson, Fen_AU
dc.contributor.authorWimberley, CAen_AU
dc.contributor.authorParmar, Aen_AU
dc.contributor.authorZahra, Den_AU
dc.contributor.authorHamze, Hen_AU
dc.contributor.authorDavis, Een_AU
dc.contributor.authorArthur, Aen_AU
dc.contributor.authorBouillot, Cen_AU
dc.contributor.authorCharil, Aen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.date.accessioned2020-03-23T02:03:45Zen_AU
dc.date.available2020-03-23T02:03:45Zen_AU
dc.date.issued2016-01-21en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractIn PET imaging, research groups have recently proposed different experimental set ups allowing multiple animals to be simultaneously imaged in a scanner in order to reduce the costs and increase the throughput. In those studies, the technical feasibility was demonstrated and the signal degradation caused by additional mice in the FOV characterized, however, the impact of the signal degradation on the outcome of a PET study has not yet been studied. Here we thoroughly investigated, using Monte Carlo simulated [18F]FDG and [11C]Raclopride PET studies, different experimental designs for whole-body and brain acquisitions of two mice and assessed the actual impact on the detection of biological variations as compared to a single-mouse setting. First, we extended the validation of the PET-SORTEO Monte Carlo simulation platform for the simultaneous simulation of two animals. Then, we designed [18F]FDG and [11C]Raclopride input mouse models for the simulation of realistic whole-body and brain PET studies. Simulated studies allowed us to accurately estimate the differences in detection between single- and dual-mode acquisition settings that are purely the result of having two animals in the FOV. Validation results showed that PET-SORTEO accurately reproduced the spatial resolution and noise degradations that were observed with actual dual phantom experiments. The simulated [18F]FDG whole-body study showed that the resolution loss due to the off-center positioning of the mice was the biggest contributing factor in signal degradation at the pixel level and a minimal inter-animal distance as well as the use of reconstruction methods with resolution modeling should be preferred. Dual mode acquisition did not have a major impact on ROI-based analysis except in situations where uptake values in organs from the same subject were compared. The simulated [11C]Raclopride study however showed that dual-mice imaging strongly reduced the sensitivity to variations when mice were positioned side-by-side while no sensitivity reduction was observed when they were facing each other. This is the first study showing the impact of different experimental designs for whole-body and brain acquisitions of two mice on the quality of the results using Monte Carlo simulated [18F]FDG and [11C]Raclopride PET studies. © 2016 Institute of Physics and Engineering in Medicineen_AU
dc.identifier.citationReilhac, A., Boisson, F., Wimberley, C., Parmar, A., Zahra, D., Hamze, H., Davis, E., Arthur, A., Bouillot, C., Charil, A., & Grégoire M. C. (2016). Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation. Physics in Medicine and Biology, 61(3), 1371-1388. doi:10.1088/0031-9155/61/3/1371en_AU
dc.identifier.govdoc8869en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issue3en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.pagination1371-1388en_AU
dc.identifier.urihttp://dx.doi.org/10.1088/0031-9155/61/3/1371en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9185en_AU
dc.identifier.volume61en_AU
dc.language.isoenen_AU
dc.publisherIOP science publishingen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectAnimalsen_AU
dc.subjectMiceen_AU
dc.subjectMonte Carlo Methoden_AU
dc.subjectBodyen_AU
dc.subjectBrainen_AU
dc.subjectPhantomsen_AU
dc.subjectOrgansen_AU
dc.titleSimultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradationen_AU
dc.typeJournal Articleen_AU
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