Tunable and noncytotoxic PET/SPECT-MRI multimodality imaging probes using colloidally stable ligand-free superparamagnetic iron oxide nanoparticles

Simple item page
dc.contributor.authorPham, THNen_AU
dc.contributor.authorLengkeek, NAen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorKim, BJen_AU
dc.contributor.authorPellegrini, PAen_AU
dc.contributor.authorBickley, SAen_AU
dc.contributor.authorTanudji, MRen_AU
dc.contributor.authorJones, SKen_AU
dc.contributor.authorHawkett, BSen_AU
dc.contributor.authorPham, BTTen_AU
dc.date.accessioned2018-09-17T06:46:18Zen_AU
dc.date.available2018-09-17T06:46:18Zen_AU
dc.date.issued2017-01-27en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractPhysiologically stable multimodality imaging probes for positron emission tomography/single-photon emission computed tomography (PET/SPECT)-magnetic resonance imaging (MRI) were synthesized using the superparamagnetic maghemite iron oxide (γ-Fe2O3) nanoparticles (SPIONs). The SPIONs were sterically stabilized with a finely tuned mixture of diblock copolymers with either methoxypolyethylene glycol (MPEG) or primary amine NH2 end groups. The radioisotope for PET or SPECT imaging was incorporated with the SPIONs at high temperature. 57Co2+ ions with a long half-life of 270.9 days were used as a model for the radiotracer to study the kinetics of radiolabeling, characterization, and the stability of the radiolabeled SPIONs. Radioactive 67Ga3+ and Cu2+-labeled SPIONs were also produced successfully using the optimized conditions from the 57Co2+-labeling process. No free radioisotopes were detected in the aqueous phase for the radiolabeled SPIONs 1 week after dispersion in phosphate-buffered saline (PBS). All labeled SPIONs were not only well dispersed and stable under physiological conditions but also noncytotoxic in vitro. The ability to design and produce physiologically stable radiolabeled magnetic nanoparticles with a finely controlled number of functionalizable end groups on the SPIONs enables the generation of a desirable and biologically compatible multimodality PET/SPECT-MRI agent on a single T2 contrast MRI probe. © 2017 Dove Press Ltd under Creative Commons v3.0, BY, NC.en_AU
dc.description.sponsorshipThis work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.en_AU
dc.identifier.citationPham, T. H.N., Lengkeek, N. A., Greguric, I., Kim, B. J., Pellegrini, P. A., Bickley, S. A., Tanudji, M.R., Jones, S. K., Hawkett, B. S., & Pham, B. T. T. (2017). Tunable and noncytotoxic PET/SPECT-MRI multimodality imaging probes using colloidally stable ligand-free superparamagnetic iron oxide nanoparticlesInternational Journal of Nanomedicine, 12, 899-909. doi:10.2147/IJN.S127171en_AU
dc.identifier.govdoc8861en_AU
dc.identifier.issn1178-2013en_AU
dc.identifier.journaltitleJournal of Nanomedicineen_AU
dc.identifier.pagination899-909en_AU
dc.identifier.urihttps://doi.org/10.2147/IJN.S127171en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9011en_AU
dc.identifier.volume12en_AU
dc.language.isoenen_AU
dc.publisherDove Press Ltden_AU
dc.subjectMagnetic resonanceen_AU
dc.subjectImagesen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectPhoton emissionen_AU
dc.subjectLight scatteringen_AU
dc.titleTunable and noncytotoxic PET/SPECT-MRI multimodality imaging probes using colloidally stable ligand-free superparamagnetic iron oxide nanoparticlesen_AU
dc.typeJournal Articleen_AU
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJN-127171-tunable-and-non-cytotoxic-pet-spect---mri-multimodality-imag_012717.pdf
Size:
1.87 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles