Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source

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dc.contributor.authorPerkins, Gen_AU
dc.contributor.authorKhatib, Oen_AU
dc.contributor.authorPeterson, MBen_AU
dc.contributor.authorKallinen, Aen_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorUng, ATen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorPascali, Gen_AU
dc.date.accessioned2020-03-23T06:52:36Zen_AU
dc.date.available2020-03-23T06:52:36Zen_AU
dc.date.issued2016-06-22en_AU
dc.description.abstractCarbon dioxide chemistry is an area of continuing growth in recent times, due to socioeconomic and environmental reasons. Several methods have now been reported for obtaining N-methylation on primary and secondary amines directly from CO2. We have translated in two microfluidic setups (Slug Flow [SF] and Tube-in-Tube [TiT]) a ruthenium (Ru)-catalyzed process previously reported using a pressure vessel. Here, we demonstrate how the SF approach is more efficient but requires more input to reach a steady state, while the TiT system is less efficient but more tuneable.We have tested these processes on three model amines and two radiopharmaceutical precursors that are routinely used in 11C chemistry. The microfluidic processes tested are also potentially more efficient than the pressure vessel counterpart, in terms of amount of Ru catalyst needed (1% vs. 10%) and projected reaction completion time. © 2016 Akadémiai Kiadó Zrt.en_AU
dc.identifier.citationPerkins, G., Khatib, O., Peterson, M., Kallinen, A., Pham, T., Ung, A., Greguric, I & Pascali, G. (2016). Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source. Journal of Flow Chemistry, 6(4), 302-308. doi:10.1556/1846.2016.00010en_AU
dc.identifier.govdoc8847en_AU
dc.identifier.issn2062-249Xen_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleJournal of Flow Chemistryen_AU
dc.identifier.pagination302-308en_AU
dc.identifier.urihttps://doi.org/10.1556/1846.2016.00010en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9195en_AU
dc.identifier.volume6en_AU
dc.language.isoenen_AU
dc.publisherAkadémiai Kiadó Zrten_AU
dc.subjectCarbon 11en_AU
dc.subjectMethylationen_AU
dc.subjectCarbon dioxideen_AU
dc.subjectRutheniumen_AU
dc.subjectCatalystsen_AU
dc.subjectAminesen_AU
dc.titleMicrofluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon sourceen_AU
dc.typeJournal Articleen_AU
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