[18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system

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dc.contributor.authorMatesic, Len_AU
dc.contributor.authorKallinen, Aen_AU
dc.contributor.authorWyatt, NAen_AU
dc.contributor.authorPham, TQen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorPascali, Gen_AU
dc.date.accessioned2018-09-17T02:16:54Zen_AU
dc.date.available2018-09-17T02:16:54Zen_AU
dc.date.issued2014-06-06en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractThe [18F]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [18F]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [18F]fluorination incorporation conditions were then translated to production-scale experiments (35–150 GBq) suitable for preclinical imaging, complete with automated HPLC–solid phase extraction purification and formulation. [18F]MEL050 was obtained in 43 ± 10 % radiochemical yield in ~50 min. © 2015 CSIRO Publishing.en_AU
dc.identifier.citationMatesic, L., Kallinen, A., Wyatt, N. A., Pham, T. Q., Greguric, I., & Pascali, G. (2015). [18F] Fluorination optimisation and the fully automated production of [18F] MEL050 using a microfluidic system. Australian Journal of Chemistry, 68(1), 69-71. doi:10.1071/CH14130en_AU
dc.identifier.govdoc8806en_AU
dc.identifier.issn1445-0038en_AU
dc.identifier.issue1en_AU
dc.identifier.journaltitleAustralian Journal of Chemistryen_AU
dc.identifier.pagination69-71en_AU
dc.identifier.urihttps://doi.org/10.1071/CH14130en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9006en_AU
dc.identifier.volume68en_AU
dc.language.isoenen_AU
dc.publisherCSIRO Publishingen_AU
dc.subjectFluorinationen_AU
dc.subjectMelaninen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectTemperature range 0400-1000 Ken_AU
dc.subjectFluorineen_AU
dc.subjectHigh-performance liquid chromatographyen_AU
dc.subjectRadiochemical analysisen_AU
dc.title[18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic systemen_AU
dc.typeJournal Articleen_AU
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