The synthesis and fluorescence profile of novel thalidomide analogues

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dc.contributor.authorKampmann, SSen_AU
dc.contributor.authorSkelton, BWen_AU
dc.contributor.authorYeoh, GCen_AU
dc.contributor.authorAbraham, LJen_AU
dc.contributor.authorLengkeek, NAen_AU
dc.contributor.authorStubbs, KAen_AU
dc.contributor.authorHeath, CHen_AU
dc.contributor.authorStewart, SGen_AU
dc.date.accessioned2020-03-17T00:12:16Zen_AU
dc.date.available2020-03-17T00:12:16Zen_AU
dc.date.issued2015-10-21en_AU
dc.date.statistics2020-03-11en_AU
dc.description.abstractHerein we describe the synthesis of various simple N-alkyl thalidomide derivatives in order to determine their fluorescence excitation and emission profile. Following this, a series of more complex fragments were attached through a Huisgen 1,3-dipolar cycloaddition providing a more diverse fluorescence profile. A thalidomide azide derivative was also found to be particularly reactive in a copper-free click reaction with two known cyclooctynes. © 2015 Elsevier Ltd.en_AU
dc.identifier.citationKampmann, S. S., Skelton, B. W., Yeoh, G. C., Abraham, L. J., Lengkeek, N. A., Stubbs, K. A.,Heath, C. H. & Stewart, S. G. (2015). The synthesis and fluorescence profile of novel thalidomide analogues. Tetrahedron, 71(42), 8140-8149. doi:10.1016/j.tet.2015.08.036en_AU
dc.identifier.govdoc8777en_AU
dc.identifier.issn0040-4020en_AU
dc.identifier.issue42en_AU
dc.identifier.journaltitleTetrahedronen_AU
dc.identifier.pagination8140-8149en_AU
dc.identifier.urihttps://doi.org/10.1016/j.tet.2015.08.036en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9162en_AU
dc.identifier.volume71en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectFluorescenceen_AU
dc.subjectProbesen_AU
dc.subjectTriazolesen_AU
dc.subjectDrugsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectLymphokinesen_AU
dc.subjectNeoplasmsen_AU
dc.titleThe synthesis and fluorescence profile of novel thalidomide analoguesen_AU
dc.typeJournal Articleen_AU
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