One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging

Simple item page
dc.contributor.authorHaskali, Men_AU
dc.contributor.authorRoselt, PDen_AU
dc.contributor.authorKaras, JAen_AU
dc.contributor.authorNoonan, Wen_AU
dc.contributor.authorWichmann, CWen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.contributor.authorHicks, RJen_AU
dc.contributor.authorHutton, CAen_AU
dc.date.accessioned2018-09-17T00:14:19Zen_AU
dc.date.available2018-09-17T00:14:19Zen_AU
dc.date.issued2013-09-16en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractThe versatile 18F‐labeled prosthetic group, 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl 2‐bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [18F]NFP, [18F]GalactoRGD — the current ‘gold standard’ tracer for imaging the expression of αVβ3 integrin — was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [18F]fluoride. © 2013 John Wiley & Sons, Ltd.en_AU
dc.identifier.citationHaskali, M. B., Roselt, P. D., Karas, J. A., Noonan, W., Wichmann, C. W., Katsifis, A., Hicks, R. J., & Hutton, C. A. (2013). One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F] fluoropropionate ([18F] NFP); improved preparation of radiolabeled peptides for PET imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 56(14), 726-730. doi:doi.org/10.1002/jlcr.3111en_AU
dc.identifier.govdoc8767en_AU
dc.identifier.issn1099-1344en_AU
dc.identifier.issue14en_AU
dc.identifier.journaltitleJournal of Labelled Compounds and Radiopharmaceuticalsen_AU
dc.identifier.pagination726-730en_AU
dc.identifier.urihttps://doi.org/10.1002/jlcr.3111en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9001en_AU
dc.identifier.volume56en_AU
dc.language.isoenen_AU
dc.publisherJohn Wiley & Sons, Ltd.en_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectPeptidesen_AU
dc.subjectFluoridesen_AU
dc.subjectProteinsen_AU
dc.subjectNeoplasmsen_AU
dc.subjectDiseasesen_AU
dc.titleOne‐step radiosynthesis of 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imagingen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles