β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment

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dc.contributor.authorCarbonell, Fen_AU
dc.contributor.authorCharil, Aen_AU
dc.contributor.authorZijdenbos, APen_AU
dc.contributor.authorEvans, ACen_AU
dc.contributor.authorBedell, BJen_AU
dc.date.accessioned2020-03-24T20:12:31Zen_AU
dc.date.available2020-03-24T20:12:31Zen_AU
dc.date.issued2014-04-16en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractPositron emission tomography (PET) studies using [18F]2-fluoro-2-deoxyglucose (FDG) have identified a well-defined pattern of glucose hypometabolism in Alzheimer's disease (AD). The assessment of the metabolic relationship among brain regions has the potential to provide unique information regarding the disease process. Previous studies of metabolic correlation patterns have demonstrated alterations in AD subjects relative to age-matched, healthy control subjects. The objective of this study was to examine the associations between β-amyloid, apolipoprotein E ɛ4 (APOE ɛ4) genotype, and metabolic correlations patterns in subjects diagnosed with mild cognitive impairment (MCI). Mild cognitive impairment subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were categorized into β-amyloid-low and β-amyloid-high groups, based on quantitative analysis of [18F]florbetapir PET scans, and APOE ɛ4 non-carriers and carriers based on genotyping. We generated voxel-wise metabolic correlation strength maps across the entire cerebral cortex for each group, and, subsequently, performed a seed-based analysis. We found that the APOE ɛ4 genotype was closely related to regional glucose hypometabolism, while elevated, fibrillar β-amyloid burden was associated with specific derangements of the metabolic correlation patterns. © 2014 International Society for Cerebral Blood Flow & Metabolism, Inc. This work is licensed under a Creative Commons Attribution 3.0en_AU
dc.identifier.citationCarbonell, F., Charil, A., Zijdenbos, A. P., Evans, A. C., & Bedell, B. J. (2014). β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment. Journal of Cerebral Blood Flow & Metabolism, 34(7), 1169. doi:10.1038/jcbfm.2014.66en_AU
dc.identifier.govdoc8694en_AU
dc.identifier.issn1559-7016en_AU
dc.identifier.issue7en_AU
dc.identifier.journaltitleJournal of Cerebral Blood Flow & Metabolismen_AU
dc.identifier.pagination1169-1179en_AU
dc.identifier.urihttp://doi.org/10.1038/jcbfm.2014.66en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9223en_AU
dc.identifier.volume34en_AU
dc.language.isoenen_AU
dc.publisherSAGE Journalsen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectAge hardeningen_AU
dc.subjectDiseasesen_AU
dc.subjectImage processingen_AU
dc.subjectMetabolismen_AU
dc.subjectGlucoseen_AU
dc.titleβ-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairmenten_AU
dc.typeJournal Articleen_AU
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