Paranoid schizophrenia is characterized by increased cannabinoid CB1 receptor binding in the dorsolateral prefrontal cortex.

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dc.contributor.authorDalton, VSen_AU
dc.contributor.authorLong, LEen_AU
dc.contributor.authorWeickert, CSen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2014-01-22T23:40:27Zen_AU
dc.date.available2014-01-22T23:40:27Zen_AU
dc.date.issued2011-07-01en_AU
dc.date.statistics2014-01-23en_AU
dc.description.abstractA number of studies suggest a dysregulation of the endogenous cannabinoid system in schizophrenia (SCZ). In the present study, we examined cannabinoid CB1 receptor (CB1R) binding and mRNA expression in the dorsolateral prefrontal cortex (DLPFC) (Brodmann's area 46) of SCZ patients and controls, post-mortem. Receptor density was investigated using autoradiography with the CB1R ligand [3H] CP 55 940 and CB1R mRNA expression was measured using quantitative RT-PCR in a cohort of 16 patients with paranoid SCZ, 21 patients with non-paranoid SCZ and 37 controls matched for age, post-mortem interval and pH. All cases were obtained from the University of Sydney Tissue Resource Centre. Results were analyzed using one-way analysis of variance (ANOVA) and post hoc Bonferroni tests and with analysis of covariance (ANCOVA) to control for demographic factors that would potentially influence CB1R expression. There was a main effect of diagnosis on [3H] CP 55 940 binding quantified across all layers of the DLPFC (F(2,71)=3.740, p=0.029). Post hoc tests indicated that this main effect was due to patients with paranoid SCZ having 22% higher levels of CB1R binding compared with the control group. When ANCOVA was employed, this effect was strengthened (F(2,67)=6.048, p=0.004) with paranoid SCZ patients differing significantly from the control (p=0.004) and from the non-paranoid group (p=0.016). In contrast, no significant differences were observed in mRNA expression between the different disease subtypes and the control group. Our findings confirm the existence of a CB1R dysregulation in SCZ and underline the need for further investigation of the role of this receptor particularly in those diagnosed with paranoid SCZ. © 2011, Nature Publishing Group.en_AU
dc.description.sponsorshipThis work was supported by the Schizophrenia Research Institute, utilizing infrastructure funding from New South Wales Health, the Macquarie Group Foundation, Neuroscience Research Australia, and the University of New South Wales. Tissues were received from the New South Wales Tissue Resource Centre at the University of Sydney, which is supported by the National Health and Medical Research Council of Australia, Schizophrenia Research Institute, National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) R24AA012725). We thank Nina Sundqvist of the New South Wales Tissue Resource Centre for her assistance.en_AU
dc.identifier.citationDalton, V. S., Long, L. E., Weickert, C. S., & Zavitsanou, K. (2011). Paranoid schizophrenia is characterized by increased cannabinoid CB1 receptor binding in the dorsolateral prefrontal cortex. Neuropsychopharmacology, 36 (8), 1620-1630. doi:10.1038/npp.2011.43en_AU
dc.identifier.govdoc5282en_AU
dc.identifier.issn0893-133Xen_AU
dc.identifier.issue8en_AU
dc.identifier.journaltitleNeuropsychopharmacologyen_AU
dc.identifier.pagination1620-1630en_AU
dc.identifier.urihttp://dx.doi.org/10.1038/npp.2011.43en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5177en_AU
dc.identifier.volume36en_AU
dc.language.isoenen_AU
dc.publisherNature Publishing Groupen_AU
dc.subjectReceptorsen_AU
dc.subjectCerebral cortexen_AU
dc.subjectRatsen_AU
dc.subjectAutoradiographyen_AU
dc.subjectDensityen_AU
dc.subjectBrainen_AU
dc.titleParanoid schizophrenia is characterized by increased cannabinoid CB1 receptor binding in the dorsolateral prefrontal cortex.en_AU
dc.typeJournal Articleen_AU
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