Tolerance of water in microfluidic radiofluorinations: a potential methodological shift?

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dc.contributor.authorPascali, Gen_AU
dc.contributor.authorDe Simone, Men_AU
dc.contributor.authorMatesic, Len_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorSalvadori, PAen_AU
dc.date.accessioned2020-03-23T05:52:11Zen_AU
dc.date.available2020-03-23T05:52:11Zen_AU
dc.date.issued2014-07-1en_AU
dc.description.abstractNucleophilic [18F]-fluorination reactions traditionally include a drying step of the labeling agent in order to achieve a successful substitution. This passage extends the time and complexity required for the whole radiotracer production, with increased hardware and detrimental effects on the radioactive recovery of such a short-lived (t½=109 min) isotope. Because the performance of radiofluorination reactions conducted under microfluidic flow conditions have been demonstrated to be more effective in terms of reaction time and yields, we have tested the tolerance to water present in this specific reaction condition, in view of eliminating the drying step in the process. To this purpose, we tested different substrates selected from typical radiofluorination intermediates. Our results show that water could be tolerated in a microfluidic environment; in particular, we observed a slight decrease in the labeling of aromatic precursors and a significant increase for iodonium salts, whereas the radiochemical yields of the other compounds studied were virtually unchanged. These findings may open the way to the possibility of simpler and faster processes for the production of new 18F-fluorinated positron emission tomography tracers. © 2014 Akadémiai Kiadóen_AU
dc.identifier.citationPascali, G., De Simone, M., Matesic, L., Greguric, I., & Salvadori, P. A. (2014). Tolerance of water in microfluidic radiofluorinations: a potential methodological shift?. Journal of Flow Chemistry, 4(2), 86-91. doi:10.1556/JFC-D-13-00034en_AU
dc.identifier.govdoc8841en_AU
dc.identifier.issn2062-249Xen_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleJournal of Flow Chemistryen_AU
dc.identifier.pagination86-91en_AU
dc.identifier.urihttps://doi.org/10.1556/JFC-D-13-00034en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9192en_AU
dc.identifier.volume4en_AU
dc.language.isoenen_AU
dc.publisherAkadémiai Kiadóen_AU
dc.subjectRadiochemistryen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectEmission computed tomographyen_AU
dc.subjectWateren_AU
dc.subjectIsotopesen_AU
dc.subjectFluorine 18en_AU
dc.titleTolerance of water in microfluidic radiofluorinations: a potential methodological shift?en_AU
dc.typeJournal Articleen_AU
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