Investigation of elemental changes in brain tissues following excitotoxic injury

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dc.contributor.authorSiegele, Ren_AU
dc.contributor.authorHowell, NRen_AU
dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorPastuovic, Zen_AU
dc.date.accessioned2015-10-31T23:46:50Zen_AU
dc.date.available2015-10-31T23:46:50Zen_AU
dc.date.issued2013-07-01en_AU
dc.date.statistics2015-10-21en_AU
dc.description.abstractRecently the ANSTO heavy ion microprobe has been used for elemental mapping of thin brain tissue sections. The fact that a very small portion of the proton energy is used for X-ray excitation combined with small variations of the major element concentrations makes μ-PIXE imaging and GeoPIXE analysis a challenging task. Excitotoxic brain injury underlies the pathology of stroke and various neurodegenerative disorders. Large fluxes in Ca+2 cytosolic concentrations are a key feature of the initiation of this pathophysiological process. In order to understand if these modifications are associated with changes in the elemental composition, several brain sections have been mapped with μ-PIXE. Increases in Ca+2 cytosolic concentrations were indicative of the pathophysiological process continuing 1 week after an initiating neural insult. We were able to measure significant variations in K and Ca concentration distribution across investigated brain tissue. These variations correlate very well with physiological changes visible in the brain tissue. Moreover, the obtained μ-PIXE results clearly demonstrate that the elemental composition changes significantly correlate with brain drauma. © 2013, Elsevier B.V.en_AU
dc.identifier.citationSiegele, R., Howell, N. R., Callaghan, P. D., & Pastuovic, Z. (2013). Investigation of elemental changes in brain tissues following excitotoxic injury. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 125-128. doi:10.1016/j.nimb.2012.12.050en_AU
dc.identifier.govdoc6202en_AU
dc.identifier.issn0168-583Xen_AU
dc.identifier.journaltitleNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atomsen_AU
dc.identifier.pagination125-128en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.nimb.2012.12.050en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6359en_AU
dc.identifier.volume306en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectPIXE analysisen_AU
dc.subjectBrainen_AU
dc.subjectPathologyen_AU
dc.subjectAnimal tissuesen_AU
dc.subjectNeurologyen_AU
dc.subjectIon microprobe analysisen_AU
dc.titleInvestigation of elemental changes in brain tissues following excitotoxic injuryen_AU
dc.typeJournal Articleen_AU
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