Microfluidics in radiopharmaceutical chemistry

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dc.contributor.authorPascali, Gen_AU
dc.contributor.authorWatts, Pen_AU
dc.contributor.authorSalvadori, PAen_AU
dc.date.accessioned2020-03-29T22:06:45Zen_AU
dc.date.available2020-03-29T22:06:45Zen_AU
dc.date.issued2013-08-01en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractThe increased demand for molecular imaging tracers useful in assessing and monitoring diseases has stimulated research towards more efficient and flexible radiosynthetic routes, including newer technologies. The traditional vessel-based approach suffers from limitations concerning flexibility, reagent mass needed, hardware requirements, large number of connections and valves, repetitive cleaning procedures and overall big footprint to be shielded from radiation. For these reasons, several research groups have started to investigate the application of the fast growing field of microfluidic chemistry to radiosynthetic procedures. After the first report in 2004, many scientific papers have been published and demonstrated the potential for increased process yields, reduced reagent use, improved flexibility and general ease of setup. This review will address definitions occurring in microfluidics as well as analyze the different approaches under two macro-categories: microvessel and microchannel. In this perspective, several works will be collected, involving the use of positron emitting species (11C, 18F, 64Cu) and the fewer examples of gamma emitting radionuclides (99mTc, 125/131I). New directions in microfluidic research applied to PET radiochemistry, future developments and challenges are also discussed. © 2013 Elsevier Inc.en_AU
dc.identifier.citationPascali, G., Watts, P., & Salvadori, P. A. (2013). Microfluidics in radiopharmaceutical chemistry. Nuclear Medicine and Biology, 40(6), 776-787. doi.:10.1016/j.nucmedbio.2013.04.004en_AU
dc.identifier.govdoc8844en_AU
dc.identifier.issn0969-8051en_AU
dc.identifier.issue6en_AU
dc.identifier.journaltitleNuclear Medicine and Biologyen_AU
dc.identifier.pagination776-787en_AU
dc.identifier.urihttps://doi.org/10.1016/j.nucmedbio.2013.04.004en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9292en_AU
dc.identifier.volume40en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectRadiopharmaceuticalsen_AU
dc.subjectChemistryen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectSingle photon emission computed tomographyen_AU
dc.subjectRadiochemistryen_AU
dc.subjectTracer techniquesen_AU
dc.titleMicrofluidics in radiopharmaceutical chemistryen_AU
dc.typeJournal Articleen_AU
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