Effects of ionizing radiation on mitochondria

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dc.contributor.authorKam, WWYen_AU
dc.contributor.authorBanati, RBen_AU
dc.date.accessioned2018-09-17T01:02:29Zen_AU
dc.date.available2018-09-17T01:02:29Zen_AU
dc.date.issued2013-12-01en_AU
dc.date.statistics2018-09-16en_AU
dc.description.abstractThe current concept of radiobiology posits that damage to the DNA in the cell nucleus is the primary cause for the detrimental effects of radiation. However, emerging experimental evidence suggests that this theoretical framework is insufficient for describing extranuclear radiation effects, particularly the response of the mitochondria, an important site of extranuclear, coding DNA. Here, we discuss experimental observations of the effects of ionizing radiation on the mitochondria at (1) the DNA and (2) functional levels. The roles of mitochondria in (3) oxidative stress and (4) late radiation effects are discussed. In this review, we summarize the current understanding of targets for ionizing radiation outside the cell nucleus. Available experimental data suggest that an increase in the tumoricidal efficacy of radiation therapy might be achievable by targeting mitochondria. Likewise, more specific protection of mitochondria and its coding DNA should reduce damage to healthy cells exposed to ionizing radiation. © 2013 Elsevier Inc.en_AU
dc.identifier.citationKam, W. W.-Y., & Banati, R. B. (2013). Effects of ionizing radiation on mitochondria. Free Radical Biology and Medicine, 65, 607-619. doi:10.1016/j.freeradbiomed.2013.07.024en_AU
dc.identifier.govdoc8773en_AU
dc.identifier.issn0891-5849en_AU
dc.identifier.journaltitleFree Radical Biology and Medicineen_AU
dc.identifier.pagination607-619en_AU
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2013.07.024en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9003en_AU
dc.identifier.volume65en_AU
dc.language.isoenen_AU
dc.publisherElsevier Inc.en_AU
dc.subjectMitochondriaen_AU
dc.subjectDNAen_AU
dc.subjectRNAen_AU
dc.subjectAnimal cellsen_AU
dc.subjectSuperoxide dismutaseen_AU
dc.subjectPhosphorylationen_AU
dc.subjectElectron transferen_AU
dc.titleEffects of ionizing radiation on mitochondriaen_AU
dc.typeJournal Articleen_AU
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