Checkpoints to the brain: directing myeloid cell migration to the central nervous system

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dc.contributor.authorHarrison-Brown, Men_AU
dc.contributor.authorLiu, GJen_AU
dc.contributor.authorBanati, RBen_AU
dc.date.accessioned2020-03-16T03:54:09Zen_AU
dc.date.available2020-03-16T03:54:09Zen_AU
dc.date.issued2016-12-02en_AU
dc.date.statistics2020-03-11en_AU
dc.description.abstractMyeloid cells are a unique subset of leukocytes with a diverse array of functions within the central nervous system during health and disease. Advances in understanding of the unique properties of these cells have inspired interest in their use as delivery vehicles for therapeutic genes, proteins, and drugs, or as “assistants” in the clean-up of aggregated proteins and other molecules when existing drainage systems are no longer adequate. The trafficking of myeloid cells from the periphery to the central nervous system is subject to complex cellular and molecular controls with several ‘checkpoints’ from the blood to their destination in the brain parenchyma. As important components of the neurovascular unit, the functional state changes associated with lineage heterogeneity of myeloid cells are increasingly recognized as important for disease progression. In this review, we discuss some of the cellular elements associated with formation and function of the neurovascular unit, and present an update on the impact of myeloid cells on central nervous system (CNS) diseases in the laboratory and the clinic. We then discuss emerging strategies for harnessing the potential of site-directed myeloid cell homing to the CNS, and identify promising avenues for future research, with particular emphasis on the importance of untangling the functional heterogeneity within existing myeloid subsets. © 2016 MDPI.en_AU
dc.identifier.articlenumber2030en_AU
dc.identifier.citationHarrison-Brown, M., Liu, G. J., & Banati, R. (2016). Checkpoints to the brain: directing myeloid cell migration to the central nervous system. International Journal of Molecular Sciences, 17(12), 2030. doi:10.3390/ijms17122030en_AU
dc.identifier.govdoc8766en_AU
dc.identifier.issn1422-0067en_AU
dc.identifier.issue12en_AU
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen_AU
dc.identifier.urihttp://dx.doi.org/ 10.3390/ijms17122030en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9159en_AU
dc.identifier.volume17en_AU
dc.language.isoenen_AU
dc.publisherMDPIen_AU
dc.subjectLeukocytesen_AU
dc.subjectCentral nervous systemen_AU
dc.subjectTherapeutic usesen_AU
dc.subjectDrug deliveryen_AU
dc.subjectProteinsen_AU
dc.subjectGenesen_AU
dc.subjectBrainen_AU
dc.subjectDiseasesen_AU
dc.titleCheckpoints to the brain: directing myeloid cell migration to the central nervous systemen_AU
dc.typeJournal Articleen_AU
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