Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B

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dc.contributor.authorFraser, BHen_AU
dc.contributor.authorHamilton, Sen_AU
dc.contributor.authorKrause-Heuer, AMen_AU
dc.contributor.authorWright, PJen_AU
dc.contributor.authorGreguric, Ien_AU
dc.contributor.authorTucker, SPen_AU
dc.contributor.authorDraffan, AGen_AU
dc.contributor.authorFokin, VVen_AU
dc.contributor.authorSharpless, KBen_AU
dc.date.accessioned2020-03-25T19:59:23Zen_AU
dc.date.available2020-03-25T19:59:23Zen_AU
dc.date.issued2012-11-29en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractThe copper catalyzed azide alkyne cycloaddition (CuAAC) reaction – the quintessential ‘click’ reaction – was used to synthesise dimers of the neuraminidase inhibitor zanamivir in high yields. The effect upon anti-viral activity of varying the linker length and the number of triazole units was explored. All dimers were tested for anti-viral activity against influenza A/Sydney/5/97 and B/Harbin/7/94 in a cytopathic effect (CPE) assay. © Royal Society of Chemistryen_AU
dc.identifier.citationFraser, B. H., Hamilton, S., Krause-Heuer, A. M., Wright, P. J., Greguric, I., Tucker, S. P., Draffan, A. G., Fokin, V. V., & Sharpless, K. B. (2013). Synthesis of 1, 4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. MedChemComm, 4(2), 383-386. doi.10.1039/C2MD20300Fen_AU
dc.identifier.govdoc8754en_AU
dc.identifier.issn2632-8682en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleMedChemCommen_AU
dc.identifier.pagination383-386en_AU
dc.identifier.urihttps://doi.org/10.1039/C2MD20300Fen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9236en_AU
dc.identifier.volume4en_AU
dc.language.isoenen_AU
dc.publisherThe Royal Society of Chemistryen_AU
dc.subjectSynthesisen_AU
dc.subjectTriazolesen_AU
dc.subjectDimersen_AU
dc.subjectInfluenzaen_AU
dc.subjectEnzyme inhibitorsen_AU
dc.subjectVirusesen_AU
dc.subjectLungsen_AU
dc.titleSynthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and Ben_AU
dc.typeJournal Articleen_AU
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