Formation of liquid-crystalline structures in the bile salt–chitosan system and triggered release from lamellar phase bile salt–chitosan capsules

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dc.contributor.authorTangso, KJen_AU
dc.contributor.authorLindberg, Sen_AU
dc.contributor.authorHartley, PGen_AU
dc.contributor.authorKnott, RBen_AU
dc.contributor.authorSpicer, Pen_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2016-10-31T01:03:01Zen_AU
dc.date.available2016-10-31T01:03:01Zen_AU
dc.date.issued2014-07-22en_AU
dc.date.statistics2016-10-31en_AU
dc.description.abstractNanostructured capsules comprised of the anionic bile salt, sodium taurodeoxycholate (STDC), and the biocompatible cationic polymer, chitosan, were prepared to assess their potential as novel tailored release nanomaterials. For comparison, a previously studied system, sodium dodecyl sulfate (SDS), and polydiallyldimethylammonium chloride (polyDADMAC) was also investigated. Crossed-polarizing light microscopy (CPLM) and small-angle X-ray scattering (SAXS) identified the presence of lamellar and hexagonal phase at the surfactant–polymer interface of the respective systems. The hydrophobic and electrostatic interactions between the oppositely charged components were studied by varying temperature and salt concentration, respectively, and were found to influence the liquid-crystalline nanostructure formed. The hexagonal phase persisted at high temperatures, however the lamellar phase structure was lost above ca. 45 °C. Both mesophases were found to dissociate upon addition of 4% NaCl solution. The rate of release of the model hydrophilic drug, Rhodamine B (RhB), from the lamellar phase significantly increased in response to changes in the solution conditions studied, suggesting that modulating the drug release from these bile salt–chitosan capsules is readily achieved. In contrast, release from the hexagonal phase capsules had no appreciable response to the stimuli applied. These findings provide a platform for these oppositely charged surfactant and polymer systems to function as stimuli-responsive or sustained-release drug delivery systems. © 2014, American Chemical Society.en_AU
dc.identifier.citationTangso, K. J., Lindberg, S., Hartley, P. G., Knott, R., Spicer, P., & Boyd, B. J. (2014). Formation of liquid-crystalline structures in the bile salt–chitosan system and triggered release from lamellar phase bile salt–chitosan capsules. ACS Applied Materials & Interfaces, 6(15), 12363-12371. doi:10.1021/am502192ten_AU
dc.identifier.govdoc7545en_AU
dc.identifier.issn1944-8252en_AU
dc.identifier.issue15en_AU
dc.identifier.journaltitleACS Applied Materials & Interfacesen_AU
dc.identifier.pagination12363-12371en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/am502192ten_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/7983en_AU
dc.identifier.volume6en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectBileen_AU
dc.subjectNanostructuresen_AU
dc.subjectSodiumen_AU
dc.subjectRhodaminesen_AU
dc.subjectSurfactantsen_AU
dc.subjectDrugsen_AU
dc.titleFormation of liquid-crystalline structures in the bile salt–chitosan system and triggered release from lamellar phase bile salt–chitosan capsulesen_AU
dc.typeJournal Articleen_AU
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