CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?

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dc.contributor.authorJiang, Len_AU
dc.contributor.authorPhang, JMen_AU
dc.contributor.authorYu, Jen_AU
dc.contributor.authorHarrop, SJen_AU
dc.contributor.authorSokolova, AVen_AU
dc.contributor.authorDuff, APen_AU
dc.contributor.authorWilik, KEen_AU
dc.contributor.authorAlkhamici, Hen_AU
dc.contributor.authorBreit, SNen_AU
dc.contributor.authorValenzuela, SMen_AU
dc.contributor.authorBrown, LJen_AU
dc.contributor.authorCurmi, PMGen_AU
dc.date.accessioned2017-08-09T01:18:24Zen_AU
dc.date.available2017-08-09T01:18:24Zen_AU
dc.date.issued2014-02-01en_AU
dc.date.statistics2016-08-30en_AU
dc.description.abstractThe CLIC proteins are a highly conserved family of metazoan proteins with the unusual ability to adopt both soluble and integral membrane forms. The physiological functions of CLIC proteins may include enzymatic activity in the soluble form and anion channel activity in the integral membrane form. CLIC proteins are associated with the ERM proteins: ezrin, radixin and moesin. ERM proteins act as cross-linkers between membranes and the cortical actin cytoskeleton. Both CLIC and ERM proteins are controlled by Rho family small GTPases. CLIC proteins, ERM and Rho GTPases act in a concerted manner to control active membrane processes including the maintenance of microvillar structures, phagocytosis and vesicle trafficking. All of these processes involve the interaction of membranes with the underlying cortical actin cytoskeleton. The relationships between Rho GTPases, CLIC proteins, ERM proteins and the membrane:actin cytoskeleton interface are reviewed. Speculative models are proposed involving the formation of localised multi-protein complexes on the membrane surface that assemble via multiple weak interactions. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. © 2013, Elsevier B.V.en_AU
dc.identifier.citationJiang, L., Phang, J. M., Yu, J., Harrop, S. J., Sokolova, A. V., Duff, A. P., Wilik, K . E., Alkhamici, H., Breit, S. N., Valenzuela, S. M., Brown, L. J., & Curmi, P. M. G. (2014). CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838(2), 643-657. doi: 10.1016/j.bbamem.2013.05.025en_AU
dc.identifier.govdoc7049en_AU
dc.identifier.issn0005-2736en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleBiochimica et Biophysica Acta (BBA) - Biomembranesen_AU
dc.identifier.pagination643-657en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbamem.2013.05.025en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/8899en_AU
dc.identifier.volume1838en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.subjectActinen_AU
dc.subjectMembranesen_AU
dc.subjectProteinsen_AU
dc.subjectPhagocytosisen_AU
dc.subjectChloridesen_AU
dc.subjectLipidsen_AU
dc.titleCLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?en_AU
dc.typeJournal Articleen_AU
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