Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain.

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dc.contributor.authorDalton, VSen_AU
dc.contributor.authorZavitsanou, Ken_AU
dc.date.accessioned2014-10-09T00:53:01Zen_AU
dc.date.available2014-10-09T00:53:01Zen_AU
dc.date.issued2010-12-01en_AU
dc.date.statistics2014-10-09en_AU
dc.description.abstractAnimal studies suggest differential effects of cannabinoids on dopamine-related behaviours in adolescence and adulthood however few studies have investigated the underlying neurochemical effects of cannabinoids during adolescence. The aim of the present study was to compare the effects of treatment with the synthetic cannabinoid, HU210, on dopamine receptor density in adolescent and adult rats. Adolescent (postnatal day (PND) 35) and adult (PND 70) rats received a single dose of 100 mu g/kg HU210 or 25,50 or 100 mu g/kg HU210 for 4 or 14 days. Dopamine D1 receptor (D1R) or D2 receptor (D2R) density was measured in the medial and lateral (CPUL) caudate putamen, nucleus accumbens, olfactory tubercle (TU) and substantia nigra (D1R only) using in vitro autoradiography. D1R and D2R densities were 1.6-1.7- and 1.1-1.4-fold higher respectively in adolescent control rats compared to adults. In adult rats, D1R density was increased by 1.2- and 1.3-fold (p < 0.05) in CPUL and TU respectively compared to controls, after 14 days of HU210 treatment. A significant overall effect of treatment (p < 0.05) on D2R density was also observed in adults after the single dose and 4 and 14 days administration of HU210. In adolescents, an overall effect of treatment on D1R density after a single exposure to HU210 was seen (p = 0.0026) but no changes in D1R or D2R densities were observed in other treatment groups. These results suggest that the adolescent rat brain does not display the same compensatory mechanisms activated in the adult brain following cannabinoid treatment. © 2010, Elsevier Ltd.en_AU
dc.identifier.citationDalton, V. S., & Zavitsanou, K. (2010). Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. Journal of Chemical Neuroanatomy, 40(4), 272-280. doi:10.1016/j.jchemneu.2010.07.005en_AU
dc.identifier.govdoc5684en_AU
dc.identifier.issn0891-0618en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleJournal of Chemical Neuroanatomyen_AU
dc.identifier.pagination272-280en_AU
dc.identifier.urihttp://dx.doi.org/10.1016/j.jchemneu.2010.07.005en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5903en_AU
dc.identifier.volume40en_AU
dc.language.isoenen_AU
dc.publisherElsevier Science BVen_AU
dc.subjectDopamineen_AU
dc.subjectNeuroregulatorsen_AU
dc.subjectBrainen_AU
dc.subjectAutoradiographyen_AU
dc.subjectRatsen_AU
dc.subjectRodentsen_AU
dc.titleDifferential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain.en_AU
dc.typeJournal Articleen_AU
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