Analytical positron range modelling in heterogeneous media for PET Monte Carlo simulation

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dc.contributor.authorLehnert, Wen_AU
dc.contributor.authorGrégoire, MCen_AU
dc.contributor.authorReilhac, Aen_AU
dc.contributor.authorMeikle, SRen_AU
dc.date.accessioned2013-12-17T00:32:34Zen_AU
dc.date.available2013-12-17T00:32:34Zen_AU
dc.date.issued2011-06-07en_AU
dc.date.statistics2013-12-17en_AU
dc.description.abstractMonte Carlo simulation codes that model positron interactions along their tortuous path are expected to be accurate but are usually slow. A simpler and potentially faster approach is to model positron range from analytical annihilation density distributions. The aims of this paper were to efficiently implement and validate such a method, with the addition of medium heterogeneity representing a further challenge. The analytical positron range model was evaluated by comparing annihilation density distributions with those produced by the Monte Carlo simulator GATE and by quantitatively analysing the final reconstructed images of Monte Carlo simulated data. In addition, the influence of positronium formation on positron range and hence on the performance of Monte Carlo simulation was investigated. The results demonstrate that 1D annihilation density distributions for different isotope–media combinations can be fitted with Gaussian functions and hence be described by simple look-up-tables of fitting coefficients. Together with the method developed for simulating positron range in heterogeneous media, this allows for efficient modelling of positron range in Monte Carlo simulation. The level of agreement of the analytical model with GATE depends somewhat on the simulated scanner and the particular research task, but appears to be suitable for lower energy positron emitters, such as 18F or 11C. No reliable conclusion about the influence of positronium formation on positron range and simulation accuracy could be drawn. © 2011 IOP Publishing LTDen_AU
dc.description.sponsorshipThe authors acknowledge the support of the Australian Research Council.en_AU
dc.identifier.citationLehnert, W., Gregoire, M. C., Reilhac, A., & Meikle, S. R. Analytical positron range modelling in heterogeneous media for PET Monte Carlo simulation. (2011). Physics in Medicine and Biology, 56(11), 3313-3335. doi:10.1088/0031-9155/56/11/009en_AU
dc.identifier.govdoc5292en_AU
dc.identifier.issn0031-9155en_AU
dc.identifier.issue11en_AU
dc.identifier.journaltitlePhysics in Medicine and Biologyen_AU
dc.identifier.pagination3313-3335en_AU
dc.identifier.urihttp://dx.doi.org/10.1088/0031-9155/56/11/009en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5096en_AU
dc.identifier.volume56en_AU
dc.language.isoenen_AU
dc.publisherIOP Publishing Ltden_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectDensityen_AU
dc.subjectPositronsen_AU
dc.subjectAnnihilationen_AU
dc.subjectElectronsen_AU
dc.subjectWateren_AU
dc.titleAnalytical positron range modelling in heterogeneous media for PET Monte Carlo simulationen_AU
dc.typeJournal Articleen_AU
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