The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

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dc.contributor.authorCamer, Den_AU
dc.contributor.authorYu, YHen_AU
dc.contributor.authorSzabo, Aen_AU
dc.contributor.authorHuang, XFen_AU
dc.date.accessioned2020-02-13T06:17:06Zen_AU
dc.date.available2020-02-13T06:17:06Zen_AU
dc.date.issued2014-04-17en_AU
dc.date.statistics2019-11-12en_AU
dc.description.abstractRecent research has uncovered the molecular mechanisms responsible for the therapeutic properties of oleanolic acid (OA), its isomer ursolic acid (UA), and derivatives. In particular, recent reports have highlighted the benefits of these compounds in the prevention and treatment of type 2 diabetes and associated life-threatening complications, such as nonalcoholic fatty liver disease, nephropathy, retinopathy, and atherosclerosis. The prevalence of type 2 diabetes is of major concern since it is reaching global epidemic levels. Treatments targeting the signaling pathways altered in type 2 diabetes are being actively investigated, and OA and UA in natural and derivative forms are potential candidates to modulate these pathways. We will explore the findings from in vitro and in vivo studies showing that these compounds: (i) improve insulin signaling and reduce hyperglycemia; (ii) reduce oxidative stress by upregulating anti-oxidants and; (iii) reduce inflammation by inhibiting proinflammatory signaling. We will discuss the molecular mechanisms underpinning these therapeutic properties in this review in order to provide a rationale for the future use of OA, UA, and their derivatives for the prevention and treatment of type 2 diabetes and associated comorbidities. © 1999-2020 John Wiley & Sons, Inc.en_AU
dc.identifier.citationCamer, D., Yu, Y., Szabo, A., & Huang, X. F. (2014). The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications. Molecular Nutrition & Food Research, 58(8), 1750-1759. doi:10.1002/mnfr.201300861en_AU
dc.identifier.govdoc8692en_AU
dc.identifier.issn1613-4133en_AU
dc.identifier.issue8en_AU
dc.identifier.journaltitleMolecular Nutrition & Food Researchen_AU
dc.identifier.pagination1750-1759en_AU
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201300861en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9114en_AU
dc.identifier.volume58en_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.subjectOleic aciden_AU
dc.subjectInflammationen_AU
dc.subjectMetabolic diseasesen_AU
dc.subjectInsulinen_AU
dc.subjectDiabetes mellitusen_AU
dc.subjectPreventive medicineen_AU
dc.titleThe molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complicationsen_AU
dc.typeJournal Articleen_AU
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