Fully automated one-pot radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine on the TracerLab FXFN module

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dc.contributor.authorBourdier, Ten_AU
dc.contributor.authorGreguric, IDen_AU
dc.contributor.authorRoselt, Pen_AU
dc.contributor.authorJackson, TWen_AU
dc.contributor.authorFaragalla, Jen_AU
dc.contributor.authorKatsifis, Aen_AU
dc.date.accessioned2020-03-24T20:47:08Zen_AU
dc.date.available2020-03-24T20:47:08Zen_AU
dc.date.issued2011-07-01en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractIntroduction: An efficient fully automated method for the radiosynthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) using the GE TracerLab FXFN synthesis module via the O-(2-tosyloxyethyl)-N-trityl-L-tyrosine tert-butylester precursor has been developed. Methods: The radiolabelling of [18F]FET involved a classical [18F]fluoride nucleophilic substitution performed in acetonitrile using potassium carbonate and Kryptofix 222, followed by acid hydrolysis using 2N hydrochloric acid. Results: [18F]FET was produced in 35±5% (n=22) yield non-decay-corrected (55±5% decay-corrected) and with radiochemical and enantiomeric purity of >99% with a specific activity of >90 GBq/μmol after 63 min of radiosynthesis including HPLC purification and formulation. Conclusion: The automated radiosynthesis provides high and reproducible yields suitable for routine clinical use. © 2011 Elsevier Inc.en_AU
dc.identifier.citationBourdier, T., Greguric, I., Roselt, P., Jackson, T., Faragalla, J., & Katsifis, A. (2011). Fully automated one-pot radiosynthesis of O-(2-[18 F] fluoroethyl)-l-tyrosine on the TracerLab FX FN module. Nuclear Medicine and Biology, 38(5), 645-651. doi:10.1016/j.nucmedbio.2011.01.001en_AU
dc.identifier.govdoc8683en_AU
dc.identifier.issn0969-8051en_AU
dc.identifier.issue5en_AU
dc.identifier.journaltitleNuclear Medicine and Biologyen_AU
dc.identifier.pagination645-651en_AU
dc.identifier.urihttps://doi.org/10.1016/j.nucmedbio.2011.01.001en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9224en_AU
dc.identifier.volume38en_AU
dc.language.isoenen_AU
dc.publisherElsevier B.V.en_AU
dc.subjectAmino acidsen_AU
dc.subjectFluorinationen_AU
dc.subjectTracer techniquesen_AU
dc.subjectSynthesisen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectNeoplasmsen_AU
dc.subjectBrainen_AU
dc.subjectPharmacologyen_AU
dc.titleFully automated one-pot radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine on the TracerLab FXFN moduleen_AU
dc.typeJournal Articleen_AU
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