Mephedrone in adolescent rats: residual memory impairment and acute but not lasting 5-HT depletion

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dc.contributor.authorMotbey, CPen_AU
dc.contributor.authorKaranges, Een_AU
dc.contributor.authorLi, KMen_AU
dc.contributor.authorWilkinson, Sen_AU
dc.contributor.authorWinstock, ARen_AU
dc.contributor.authorRamsey, Jen_AU
dc.contributor.authorHicks, Cen_AU
dc.contributor.authorKendig, MDen_AU
dc.contributor.authorWyatt, NAen_AU
dc.contributor.authorCallaghan, PDen_AU
dc.contributor.authorMcGregor, ISen_AU
dc.date.accessioned2020-03-29T22:18:54Zen_AU
dc.date.available2020-03-29T22:18:54Zen_AU
dc.date.issued2012-09-18en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractMephedrone (4-methylmethcathinone, MMC) is a popular recreational drug, yet its potential harms are yet to be fully established. The current study examined the impact of single or repeated MMC exposure on various neurochemical and behavioral measures in rats. In Experiment 1 male adolescent Wistar rats received single or repeated (once a day for 10 days) injections of MMC (30 mg/kg) or the comparator drug methamphetamine (METH, 2.5 mg/kg). Both MMC and METH caused robust hyperactivity in the 1 h following injection although this effect did not tend to sensitize with repeated treatment. Striatal dopamine (DA) levels were increased 1 h following either METH or MMC while striatal and hippocampal serotonin (5-HT) levels were decreased 1 h following MMC but not METH. MMC caused greater increases in 5-HT metabolism and greater reductions in DA metabolism in rats that had been previously exposed to MMC. Autoradiographic analysis showed no signs of neuroinflammation ([125I]CLINDE ligand used as a marker for translocator protein (TSPO) expression) with repeated exposure to either MMC or METH. In Experiment 2, rats received repeated MMC (7.5, 15 or 30 mg/kg once a day for 10 days) and were examined for residual behavioral effects following treatment. Repeated high (30 mg/kg) dose MMC produced impaired novel object recognition 5 weeks after drug treatment. However, no residual changes in 5-HT or DA tissue levels were observed at 7 weeks post-treatment. Overall these results show that MMC causes acute but not lasting changes in DA and 5-HT tissue concentrations. MMC can also cause long-term memory impairment. Future studies of cognitive function in MMC users are clearly warranted. © 2012 Motbey et al.en_AU
dc.identifier.articlenumbere45473en_AU
dc.identifier.citationMotbey, C. P., Karanges, E., Li, K. M., Wilkinson, S., Winstock, A. R., Ramsey, J., Hicks, C., Kendig, M. D., Wyatt, N., Callaghan, P. D., & McGregor, I. S. (2012). Mephedrone in adolescent rats: residual memory impairment and acute but not lasting 5-HT depletion. PloS one, 7(9), e45473. doi:10.1371/journal.pone.0045473en_AU
dc.identifier.govdoc8826en_AU
dc.identifier.issn1932-6203en_AU
dc.identifier.issue9en_AU
dc.identifier.journaltitlePloS oneen_AU
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0045473en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9293en_AU
dc.identifier.volume7en_AU
dc.language.isoenen_AU
dc.publisherPLOSen_AU
dc.subjectRatsen_AU
dc.subjectDrugsen_AU
dc.subjectSerotoninen_AU
dc.subjectDopamineen_AU
dc.subjectInflammationen_AU
dc.subjectBioelectricityen_AU
dc.subjectCocaineen_AU
dc.subjectAnalepticsen_AU
dc.subjectBrainen_AU
dc.titleMephedrone in adolescent rats: residual memory impairment and acute but not lasting 5-HT depletionen_AU
dc.typeJournal Articleen_AU
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