Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies

dc.contributor.authorMiddleton, RJen_AU
dc.contributor.authorLiu, GJen_AU
dc.contributor.authorBanati, RBen_AU
dc.date.accessioned2020-03-29T22:59:49Zen_AU
dc.date.available2020-03-29T22:59:49Zen_AU
dc.date.issued2015-08-03en_AU
dc.date.statistics2020-03-20en_AU
dc.description.abstractThe highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands. © 2015 Authorsen_AU
dc.identifier.citationMiddleton, R. J., Liu, G.-J., & Banati, R. B. (2015). Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies. Biochemical Society Transactions, 43(4), 553-558. doi:10.1042/BST20150039en_AU
dc.identifier.govdoc8822en_AU
dc.identifier.issn1470-8752en_AU
dc.identifier.issue4en_AU
dc.identifier.journaltitleBiochemical Society Transactionsen_AU
dc.identifier.pagination553-558en_AU
dc.identifier.urihttps://doi.org/10.1042/BST20150039en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/9295en_AU
dc.identifier.volume43en_AU
dc.language.isoenen_AU
dc.publisherPortland Press Limiteden_AU
dc.subjectEnergyen_AU
dc.subjectMetabolismen_AU
dc.subjectMitochondriaen_AU
dc.subjectProteinsen_AU
dc.subjectMiceen_AU
dc.titleGuwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studiesen_AU
dc.typeJournal Articleen_AU
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