Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies
dc.contributor.author | Middleton, RJ | en_AU |
dc.contributor.author | Liu, GJ | en_AU |
dc.contributor.author | Banati, RB | en_AU |
dc.date.accessioned | 2020-03-29T22:59:49Z | en_AU |
dc.date.available | 2020-03-29T22:59:49Z | en_AU |
dc.date.issued | 2015-08-03 | en_AU |
dc.date.statistics | 2020-03-20 | en_AU |
dc.description.abstract | The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands. © 2015 Authors | en_AU |
dc.identifier.citation | Middleton, R. J., Liu, G.-J., & Banati, R. B. (2015). Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies. Biochemical Society Transactions, 43(4), 553-558. doi:10.1042/BST20150039 | en_AU |
dc.identifier.govdoc | 8822 | en_AU |
dc.identifier.issn | 1470-8752 | en_AU |
dc.identifier.issue | 4 | en_AU |
dc.identifier.journaltitle | Biochemical Society Transactions | en_AU |
dc.identifier.pagination | 553-558 | en_AU |
dc.identifier.uri | https://doi.org/10.1042/BST20150039 | en_AU |
dc.identifier.uri | http://apo.ansto.gov.au/dspace/handle/10238/9295 | en_AU |
dc.identifier.volume | 43 | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Portland Press Limited | en_AU |
dc.subject | Energy | en_AU |
dc.subject | Metabolism | en_AU |
dc.subject | Mitochondria | en_AU |
dc.subject | Proteins | en_AU |
dc.subject | Mice | en_AU |
dc.title | Guwiyang Wurra–‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies | en_AU |
dc.type | Journal Article | en_AU |
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