pH-responsive micelles based on caprylic acid

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dc.contributor.authorSalentinig, Sen_AU
dc.contributor.authorPhan, Sen_AU
dc.contributor.authorDarwish, TAen_AU
dc.contributor.authorKirby, Nen_AU
dc.contributor.authorBoyd, BJen_AU
dc.contributor.authorGilbert, EPen_AU
dc.date.accessioned2016-10-25T23:30:14Zen_AU
dc.date.available2016-10-25T23:30:14Zen_AU
dc.date.issued2014-06-06en_AU
dc.date.statistics2016-10-26en_AU
dc.description.abstractFree fatty acids play a vital role as fuel for cells and in lipid metabolism. During lipid digestion in the gastrointestinal tract, triglycerides are hydrolyzed, resulting in free fatty acid and monoglyceride amphiphilic products. These components, together with bile salts, are responsible for the transport of lipids and poorly water-soluble nutrients and xenobiotics from the intestine into the circulatory system of the body. In this study, we show that the self-assembly of digestion products from medium-chain triglycerides (tricaprylin) in combination with bile salt and phospholipid is highly pH-responsive. Individual building blocks of caprylic acid within the mixed colloidal structures are mapped using a combination of small-angle X-ray and neutron scattering combined with both solvent contrast variation and selective deuteration. Modeling of the scattering data shows transitions in the size and shape of the micelles in combination with a transfer of the caprylic acid from the core of the micelles to the shell or into the bulk water upon increasing pH. The results help to understand the process of lipid digestion with a focus on colloidal structure formation and transformation for the delivery of triglyceride lipids and other hydrophobic functional molecules. © 2014, American Chemical Society.en_AU
dc.identifier.citationSalentinig, S., Phan, S., Darwish, T. A., Kirby, N., Boyd, B. J., & Gilbert, E. P. (2014). pH-responsive micelles based on caprylic acid. Langmuir, 30(25), 7296-7303. doi:10.1021/la500835een_AU
dc.identifier.govdoc7422en_AU
dc.identifier.issn1520-5827en_AU
dc.identifier.issue25en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination7296-7303en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la500835een_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/7900en_AU
dc.identifier.volume30en_AU
dc.language.isoenen_AU
dc.publisherACS Publicationsen_AU
dc.subjectLipidsen_AU
dc.subjectMetabolismen_AU
dc.subjectXenobioticsen_AU
dc.subjectTriglyceridesen_AU
dc.subjectMoleculesen_AU
dc.titlepH-responsive micelles based on caprylic aciden_AU
dc.typeJournal Articleen_AU
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