SNARE-ing the structures of Sec1/Munc18 proteins

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dc.contributor.authorArchbold, JKen_AU
dc.contributor.authorWhitten, AEen_AU
dc.contributor.authorHu, SHen_AU
dc.contributor.authorCollins, BMen_AU
dc.contributor.authorMartin, JLen_AU
dc.date.accessioned2015-12-28T01:08:01Zen_AU
dc.date.available2015-12-28T01:08:01Zen_AU
dc.date.issued2014-12-01en_AU
dc.date.statistics2015-12-19en_AU
dc.description.abstractMembrane fusion is essential for cellular transport in eukaryotes. Abnormalities contribute to a wide range of diseases including diabetes and neurological disorders. A key regulator of SNARE-mediated membrane fusion is the Sec1/Munc18 (SM) protein family. Universal structural features of SM proteins have been identified that affect the way these interact with their partner Syntaxin SNARE proteins. Whilst the molecular basis for SM-regulated SNARE complex formation has been extensively studied, it remains poorly understood. Recent crystal structures of SM proteins alone or in complex have provided new insight. Here we examine the available structural information on SM proteins for clues to how these enigmatic proteins might regulate SNARE complex assembly and membrane fusion. © 2014, Elsevier Ltd.en_AU
dc.identifier.citationArchbold, J. K., Whitten, A. E., Hu, S.-H., Collins, B. M., & Martin, J. L. (2014). SNARE-ing the structures of Sec1/Munc18 proteins. Current Opinion in Structural Biology, 29, 44-51. doi:10.1016/j.sbi.2014.09.003en_AU
dc.identifier.govdoc6350en_AU
dc.identifier.issn0959-440Xen_AU
dc.identifier.journaltitleCurrent Opinion in Structural Biologyen_AU
dc.identifier.pagination44-51en_AU
dc.identifier.urihttps://doi.org/10.1016/j.sbi.2014.09.003en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/6482en_AU
dc.identifier.volume29en_AU
dc.language.isoenen_AU
dc.publisherElsevier BVen_AU
dc.subjectMembranesen_AU
dc.subjectChromosomal aberrationsen_AU
dc.subjectDiabetes mellitusen_AU
dc.subjectProteinsen_AU
dc.subjectDiseasesen_AU
dc.subjectMoleculesen_AU
dc.titleSNARE-ing the structures of Sec1/Munc18 proteinsen_AU
dc.typeJournal Articleen_AU
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