Transfer of lipid between triglyceride dispersions and lyotropic liquid crystal nanostructured particles using time-resolved SAXS

Simple item page
dc.contributor.authorTilley, AJen_AU
dc.contributor.authorDong, YDen_AU
dc.contributor.authorChong, JYTen_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorKirby, Nen_AU
dc.contributor.authorDrummond, CJen_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2013-10-03T04:07:43Zen_AU
dc.date.available2013-10-03T04:07:43Zen_AU
dc.date.issued2012-04-16en_AU
dc.date.statistics2013-10-03en_AU
dc.description.abstractLipid-based lyotropic liquid crystalline nanostructured phases, such as the reverse bicontinuous cubic phase (V-2) and the reverse hexagonal phase (H-2), can be dispersed into submicron sized particles with often preserved internal nanostructure, termed cubosomes and hexosomes respectively. The internal nanostructure of the particles imparts desirable characteristics such as the ability to provide sustained release of active ingredients but is susceptible to change upon the incorporation of other lipids used as an active ingredient delivery system. These are complex systems in which the direction of lipid transfer, role of the stabiliser and formation of different phase structures, such as the frustrated H-2 phase are all likely to play a role but are not yet completely understood. Consequently, we have investigated the interparticle transfer of lipids between cubosomes/hexosomes and other dispersed lipids, namely triglycerides and vitamin E acetate emulsions. Time-resolved synchrotron small angle X-ray scattering was used to follow changes to nanostructure, attributed to the transfer of lipids into or out of the cubosomes. It was found that transfer of lipid occurred due to compositional ripening via a micelle-mediated mechanism, evident from the rate of lipid transfer increasing with Pluronic concentration. The rate of transfer of alkanes between liquid crystalline particles and emulsions has been shown previously to depend inversely on chain length. However in the triglyceride systems in the current study, the rate of lipid transfer (trilaurin > tricaprylin > supercooled trimyristin >> crystallised trimyristin and tristearin) did not decrease with increase in the chain length of triglyceride as might be anticipated. The equilibrium phase diagrams of triglyceride + phytantriol in excess water were determined. These diagrams showed that the transfer of phytantriol away from cubosomes to the emulsions, which increases the local triglyceride to phytantriol concentration in the cubosomes, would require formation of H-2 phase more readily for tricaprylin than for trilaurin. Therefore, the lack of correlation of transfer rate with chain length of the triglyceride was attributed to the system seeking to avoid the unfavourable formation of the H-2 phase, competing with the driving force from the entropy of mixing, and was therefore attributed as the reason for the greater rate of transfer of trilaurin compared to the less lipophilic tricaprylin. © 2012 Royal Society of Chemistryen_AU
dc.identifier.citationTilley, A. J., Dong, Y. D., Chong, J. Y. T., Hanley, T., Kirby, N., Drummond, C. J., & Boyd, B. J. (2012). Transfer of lipid between triglyceride dispersions and lyotropic liquid crystal nanostructured particles using time-resolved SAXS. Soft Matter, 8 (20), 5696-5708. doi:10.1039/c2sm00048ben_AU
dc.identifier.govdoc5134en_AU
dc.identifier.issn1744-683Xen_AU
dc.identifier.issue20en_AU
dc.identifier.journaltitleSoft Matteren_AU
dc.identifier.pagination5696en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/c2sm00048ben_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4758en_AU
dc.identifier.volume8en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistry.en_AU
dc.subjectLiquid crystalsen_AU
dc.subjectNanostructuresen_AU
dc.subjectParticlesen_AU
dc.subjectDispersionsen_AU
dc.subjectTriglyceridesen_AU
dc.subjectSynchrotronsen_AU
dc.titleTransfer of lipid between triglyceride dispersions and lyotropic liquid crystal nanostructured particles using time-resolved SAXSen_AU
dc.typeJournal Articleen_AU
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles