Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing no-donor prodrugs activated by b-lactamase

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dc.contributor.authorYepuri, NRen_AU
dc.contributor.authorBarraud, Nen_AU
dc.contributor.authorMohammadi, NSen_AU
dc.contributor.authorKardak, BGen_AU
dc.contributor.authorKjelleberg, Sen_AU
dc.contributor.authorRice, SAen_AU
dc.contributor.authorKelso, MJen_AU
dc.date.accessioned2013-11-07T04:51:11Zen_AU
dc.date.available2013-11-07T04:51:11Zen_AU
dc.date.issued2013-01-01en_AU
dc.date.statistics2013-11-07en_AU
dc.description.abstractUse of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3[prime or minute]-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme [small beta]-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. © 2013, Royal Society of Chemistryen_AU
dc.identifier.citationYepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., & Kelso, M. J. (2013). Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing no-donor prodrugs activated by b-lactamase. Chemical Communications, 49 (42), 4791-4793. doi:10.1039/c3cc40869hen_AU
dc.identifier.govdoc5123en_AU
dc.identifier.issn1359-7345en_AU
dc.identifier.issue42en_AU
dc.identifier.journaltitleChemical Communicationsen_AU
dc.identifier.pagination4791-4793en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/c3cc40869hen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4899en_AU
dc.identifier.volume49en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chemistryen_AU
dc.subjectNitric oxideen_AU
dc.subjectIsomerizationen_AU
dc.subjectChemistryen_AU
dc.subjectDispersionsen_AU
dc.subjectAntibodiesen_AU
dc.subjectDrugsen_AU
dc.titleSynthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing no-donor prodrugs activated by b-lactamaseen_AU
dc.typeJournal Articleen_AU
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