Effect of functionalized gold nanoparticles on floating lipid bilayers

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dc.contributor.authorTatur, Sen_AU
dc.contributor.authorMaccarini, Men_AU
dc.contributor.authorBarker, Ren_AU
dc.contributor.authorNelson, Aen_AU
dc.contributor.authorFragneto, Gen_AU
dc.date.accessioned2013-10-10T04:16:35Zen_AU
dc.date.available2013-10-10T04:16:35Zen_AU
dc.date.issued2013-06-04en_AU
dc.date.statistics2013-10-10en_AU
dc.description.abstractThe development of novel nano-engineered materials poses important questions regarding the impact of these new materials on living systems. Possible adverse effects must be assessed in order to prevent risks for health and the environment. On the other hand, a thorough understanding of their interaction with biological systems might also result in the creation of novel biomedical applications. We present a study on the interaction of model lipid membranes with gold nanoparticles (AuNP) of different surface modifications. Neutron reflectometry experiments on zwitterionic lipid double bilayers were performed in the presence of AuNP functionalized with cationic and anionic head groups. Structural information was obtained that provided insight into the fate of the AuNPs with regard to the integrity of the model cell membranes. The AuNPs functionalized with cationic head groups penetrate into the hydrophobic moiety of the lipid bilayers and cause membrane disruption at an increased concentration. In contrast, the AuNPs functionalized with anionic head groups do not enter but seem to impede the destruction of the lipid bilayer at an alkaline pH. The information obtained might influence the strategy for a better nanoparticle risk assessment based on a surface charge evaluation and contribute to nano-safety considerations during their design. © 2013, American Chemical Society.en_AU
dc.identifier.citationTatur, S., Maccarini, M., Barker, R., Nelson, A., & Fragneto, G. (2013). Effect of functionalized gold nanoparticles on floating lipid bilayers. Langmuir, 29 (22), 6606-6614. doi:10.1021/la401074yen_AU
dc.identifier.govdoc5093en_AU
dc.identifier.issn0743-7463en_AU
dc.identifier.issue22en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination6606-6614en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la401074yen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4783en_AU
dc.identifier.volume29en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectMembranesen_AU
dc.subjectAdsorptionen_AU
dc.subjectHydrationen_AU
dc.subjectToxicityen_AU
dc.subjectSurfacesen_AU
dc.subjectGolden_AU
dc.titleEffect of functionalized gold nanoparticles on floating lipid bilayersen_AU
dc.typeJournal Articleen_AU
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