Structural effects of the antimicrobial peptide maculatin 1.1 on supported lipid bilayers

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dc.contributor.authorFernandez, DIen_AU
dc.contributor.authorBrun, APen_AU
dc.contributor.authorLee, THen_AU
dc.contributor.authorBansal, PSen_AU
dc.date.accessioned2013-04-09T00:58:43Zen_AU
dc.date.available2013-04-09T00:58:43Zen_AU
dc.date.issued2013-01-01en_AU
dc.date.statistics2013-04-08en_AU
dc.description.abstractThe interactions of the antimicrobial peptide maculatin 1.1 (GLFGVLAKVAAHVVPAIAEHF-NH2) with model phospholipid membranes were studied by use of dual polarisation interferometry and neutron reflectometry and dimyristoylphosphatidylcholine (DMPC) and mixed DMPC–dimyristoylphosphatidylglycerol (DMPG)-supported lipid bilayers chosen to mimic eukaryotic and prokaryotic membranes, respectively. In DMPC bilayers concentration-dependent binding and increasing perturbation of bilayer order by maculatin were observed. By contrast, in mixed DMPC–DMPG bilayers, maculatin interacted more strongly and in a concentration-dependent manner with retention of bilayer lipid order and structure, consistent with pore formation. These results emphasise the importance of membrane charge in mediating antimicrobial peptide activity and emphasise the importance of using complementary methods of analysis in probing the mode of action of antimicrobial peptides.© 2013, Springer.en_AU
dc.identifier.citationFernandez, D.I., Brun, A.P., Lee, T. H., & Bansal, P. (2013). Structural effects of the antimicrobial peptide maculatin 1.1 on supported lipid bilayers. European Biophysics Journal, 42, 47-59. doi:10.1007/s00249-012-0796-6en_AU
dc.identifier.govdoc4907en_AU
dc.identifier.issn0175-7571en_AU
dc.identifier.journaltitleEuropean Biophysics Journalen_AU
dc.identifier.pagination47-59en_AU
dc.identifier.urihttp://dx.doi.org/10.1007/s00249-012-0796-6en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/4533en_AU
dc.identifier.volume42en_AU
dc.language.isoenen_AU
dc.publisherSpringeren_AU
dc.subjectMembranesen_AU
dc.subjectPeptidesen_AU
dc.subjectPolarizationen_AU
dc.subjectInterferometryen_AU
dc.subjectNeutron reflectorsen_AU
dc.subjectOrientationen_AU
dc.titleStructural effects of the antimicrobial peptide maculatin 1.1 on supported lipid bilayersen_AU
dc.typeJournal Articleen_AU
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