Protein surface and core dynamics show concerted hydration-dependent activation

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dc.contributor.authorWood, Ken_AU
dc.contributor.authorGallat, FXen_AU
dc.contributor.authorOtten, Ren_AU
dc.contributor.authorvan Heel, AJen_AU
dc.contributor.authorLethier, Men_AU
dc.contributor.authorvan Eijck, Len_AU
dc.contributor.authorMoulin, Men_AU
dc.contributor.authorHaertlein, Men_AU
dc.contributor.authorWeik, Men_AU
dc.contributor.authorMulder, FAAen_AU
dc.date.accessioned2014-04-03T02:34:00Zen_AU
dc.date.available2014-04-03T02:34:00Zen_AU
dc.date.issued2013-01-01en_AU
dc.date.statistics2014-04-03en_AU
dc.description.abstractBy specifically labeling leucine/valine methyl groups and lysine side chains “inside” and “outside” dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition. © 2013, Wiley-VCH Verlag GmbH & Co. KGaAen_AU
dc.identifier.citationWood, K., Gallat, F. X., Otten, R., van Heel, A. J., Lethier, M., van Eijck, L., Moulin, M., Haertlein, M., Weik, M., & Mulder, F. A. A. (2013). Protein surface and core dynamics show concerted hydration-dependent activation. Angewandte Chemie International Edition, 52(2), 665-668. doi:10.1002/anie.201205898en_AU
dc.identifier.govdoc4752en_AU
dc.identifier.issn1433-7851en_AU
dc.identifier.issue2en_AU
dc.identifier.journaltitleAngewandte Chemie International Editionen_AU
dc.identifier.pagination665-668en_AU
dc.identifier.urihttp://dx.doi.org/10.1002/anie.201205898en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5397en_AU
dc.identifier.volume52en_AU
dc.language.isoenen_AU
dc.publisherWiley-V C H Verlag GMBHen_AU
dc.subjectHydrationen_AU
dc.subjectIsotopesen_AU
dc.subjectNeutron spectroscopyen_AU
dc.subjectProteinsen_AU
dc.subjectEnzyme activityen_AU
dc.subjectMyoglobinen_AU
dc.subjectLysozymeen_AU
dc.subjectGlassen_AU
dc.titleProtein surface and core dynamics show concerted hydration-dependent activationen_AU
dc.typeJournal Articleen_AU
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