Controlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiation

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dc.contributor.authorFong, WKen_AU
dc.contributor.authorHanley, TLen_AU
dc.contributor.authorThierry, Ben_AU
dc.contributor.authorKirby, Nen_AU
dc.contributor.authorWaddington, LJen_AU
dc.contributor.authorBoyd, BJen_AU
dc.date.accessioned2014-04-17T00:38:24Zen_AU
dc.date.available2014-04-17T00:38:24Zen_AU
dc.date.issued2012-10-09en_AU
dc.date.statistics2014-04-17en_AU
dc.description.abstractLipid-based liquid-crystalline matrixes provide a unique prospect for stimuli-responsive nanomaterials, attributed to the ability to effect self-assembly of the lipids at the molecular level. Differences in liquid crystal nanostructure have previously been shown to change drug diffusion and hence release, with research progressing toward the use of in situ changes to nanostructure to control drug release. Toward this goal, we have previously communicated the ability to switch between nonlamellar structures using gold nanorod (GNR)-phytantriol-based liquid-crystalline hybrid nanomaterials as near-infrared light responsive systems (Fong et al. Langmuir 2010, 26, 6136-6139). In this study, the effect of laser activation on matrix nanostructure with changes in a number of system variables including lipid composition, GNR aspect ratio, GNR concentration, and laser pulse time were investigated. The nanostructure of the matrix was followed using small-angle X-ray scattering, while both cryoFESEM and cryoTEM were used to visualize the effect of GNR incorporation into the liquid crystal nanostructure. The system response was found to be dependent on all variables, thus demonstrating the potential of these nanocomposite materials as reversible "on-demand" drug delivery applications. © 2012, American Chemical Society.en_AU
dc.identifier.citationFong, W. K., Hanley, T. L., Thierry, B., Kirby, N., Waddington, L. J., & Boyd, B. J. (2012). Controlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiation. Langmuir, 28(40), 14450-14460. doi:10.1021/la302901qen_AU
dc.identifier.govdoc4580en_AU
dc.identifier.issn0743-7463en_AU
dc.identifier.issue40en_AU
dc.identifier.journaltitleLangmuiren_AU
dc.identifier.pagination14450-14460en_AU
dc.identifier.urihttp://dx.doi.org/10.1021/la302901qen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5444en_AU
dc.identifier.volume28en_AU
dc.language.isoenen_AU
dc.publisherAmerican Chemical Societyen_AU
dc.subjectDrugsen_AU
dc.subjectLipidsen_AU
dc.subjectWateren_AU
dc.subjectIn vivoen_AU
dc.subjectToxicityen_AU
dc.subjectSurfacesen_AU
dc.titleControlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiationen_AU
dc.typeJournal Articleen_AU
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