Elucidation of density profile of self-assembled sitosterol plus oryzanol tubules with small-angle neutron scattering

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dc.contributor.authorBot, Aen_AU
dc.contributor.authorGilbert, EPen_AU
dc.contributor.authorBouwman, WGen_AU
dc.contributor.authorSawalha, Hen_AU
dc.contributor.authorden Adel, Ren_AU
dc.contributor.authorGaramus, VMen_AU
dc.contributor.authorVenema, Pen_AU
dc.contributor.authorvan der Linden, Een_AU
dc.contributor.authorFloter, Een_AU
dc.date.accessioned2014-04-16T00:11:29Zen_AU
dc.date.available2014-04-16T00:11:29Zen_AU
dc.date.issued2012-01-01en_AU
dc.date.statistics2014-04-16en_AU
dc.description.abstractSmall-angle neutron scattering (SANS) experiments have been performed on self-assembled tubules of sitosterol and oryzanol in triglyceride oils to investigate details of their structure. Alternative organic phases (deuterated and non-deuterated decane, limonene, castor oil and eugenol) were used to both vary the contrast with respect to the tubules and investigate the influence of solvent chemistry. The tubules were found to be composed of an inner and an outer shell containing the androsterol group of sitosterol or oryzanol and the ferulic acid moieties in the oryzanol molecule, respectively. While the inner shell has previously been detected in SAXS experiments, the outer shell was not discernible due to similar scattering length density with respect to the surrounding solvent for X-rays. By performing contrast variation SANS experiments, both for the solvent and structurant, a far more detailed description of the self-assembled system is obtainable. A model is introduced to fit the SANS data; we find that the dimensions of the inner shell agree quantitatively with the analysis performed in earlier SAXS data (radius of 39.4 +/- 5.6 angstrom for core and inner shell together, wall thickness of 15.1 +/- 5.5 angstrom). However, the newly revealed outer shell was found to be thinner than the inner shell (wall thickness 8.0 +/- 6.5 angstrom). The changes in the scattering patterns may be explained in terms of the contrast between the structurant and the organic phase and does not require any subtle indirect effects caused by the presence of water, other than water promoting the formation of sitosterol monohydrate in emulsions with aqueous phases with high water activity. © 2012, Royal Society of Chemistry.en_AU
dc.identifier.citationBot, A., Gilbert, E. P., Bouwman, W. G., Sawalha, H., den Adel, R., Garamus, V. M., Venema, P., van der Linden, E., & Floter, E. (2012). Elucidation of density profile of self-assembled sitosterol plus oryzanol tubules with small-angle neutron scattering. Faraday Discussions, 158, 223-238. doi:10.1039/c2fd20020aen_AU
dc.identifier.govdoc4578en_AU
dc.identifier.issn1359-6640en_AU
dc.identifier.journaltitleFaraday Discussionsen_AU
dc.identifier.pagination223-238en_AU
dc.identifier.urihttp://dx.doi.org/10.1039/c2fd20020aen_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5436en_AU
dc.identifier.volume158en_AU
dc.language.isoenen_AU
dc.publisherRoyal Society of Chenistryen_AU
dc.subjectNeutronsen_AU
dc.subjectVegetable oilsen_AU
dc.subjectOilsen_AU
dc.subjectSolventsen_AU
dc.subjectEmulsionsen_AU
dc.subjectWaxesen_AU
dc.titleElucidation of density profile of self-assembled sitosterol plus oryzanol tubules with small-angle neutron scatteringen_AU
dc.typeJournal Articleen_AU
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